Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women
This study aims to explore the relationship between the iodine status and thyroid dysfunction (TD) in pregnant women and establish a model to guide them to prevent excessive iodine intake. A total of 515 pregnant women were enrolled in the study. Urinary iodine concentration (UIC), thyroid hormones,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-12-01
|
| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2021-0142 |
| _version_ | 1797998088942518272 |
|---|---|
| author | Zhou Yuhan Chen Fen Wang Lingyu Tian Chunhui Zhang Shuo Ding Feifei Deng Jie |
| author_facet | Zhou Yuhan Chen Fen Wang Lingyu Tian Chunhui Zhang Shuo Ding Feifei Deng Jie |
| author_sort | Zhou Yuhan |
| collection | DOAJ |
| description | This study aims to explore the relationship between the iodine status and thyroid dysfunction (TD) in pregnant women and establish a model to guide them to prevent excessive iodine intake. A total of 515 pregnant women were enrolled in the study. Urinary iodine concentration (UIC), thyroid hormones, and thyroid autoantibodies were measured, and then a logistic regression model was established. The median UIC of pregnant women was 174 ± 120 μg/L. Multivariate logistic regression analysis indicated that multivitamin supplements containing iodine and frequent seafood consumption were risk factors for excessive iodine (UIC ≥500 μg/L). Besides, excessive iodine was a risk factor for TD. Iodine excess was associated with a high prevalence of TD in pregnant women, especially TPOAb-positive women (P < 0.05). A logistic regression model based on potential risk factors was established to predict the risk of excessive iodine intake among pregnant women and provide guidance to minimize the risk of excessive iodine intake, thus reducing the risk of TD. |
| first_indexed | 2024-04-11T10:42:58Z |
| format | Article |
| id | doaj.art-1662107122e648429788356c998ca964 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-11T10:42:58Z |
| publishDate | 2021-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-1662107122e648429788356c998ca9642022-12-22T04:29:08ZengDe GruyterOpen Life Sciences2391-54122021-12-011611357136410.1515/biol-2021-0142Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant womenZhou Yuhan0Chen Fen1Wang Lingyu2Tian Chunhui3Zhang Shuo4Ding Feifei5Deng Jie6Department of Obstetrics, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, No. 15 Jiefang Road, Fancheng District, Xiangyang, 441000, People’s Republic of ChinaDepartment of Obstetrics, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, No. 15 Jiefang Road, Fancheng District, Xiangyang, 441000, People’s Republic of ChinaDepartment of Obstetrics, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, No. 15 Jiefang Road, Fancheng District, Xiangyang, 441000, People’s Republic of ChinaDepartment of Obstetrics, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, No. 15 Jiefang Road, Fancheng District, Xiangyang, 441000, People’s Republic of ChinaDepartment of Technology, Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai 201204, People’s Republic of ChinaDepartment of Technology, Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai 201204, People’s Republic of ChinaDepartment of Obstetrics, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, No. 15 Jiefang Road, Fancheng District, Xiangyang, 441000, People’s Republic of ChinaThis study aims to explore the relationship between the iodine status and thyroid dysfunction (TD) in pregnant women and establish a model to guide them to prevent excessive iodine intake. A total of 515 pregnant women were enrolled in the study. Urinary iodine concentration (UIC), thyroid hormones, and thyroid autoantibodies were measured, and then a logistic regression model was established. The median UIC of pregnant women was 174 ± 120 μg/L. Multivariate logistic regression analysis indicated that multivitamin supplements containing iodine and frequent seafood consumption were risk factors for excessive iodine (UIC ≥500 μg/L). Besides, excessive iodine was a risk factor for TD. Iodine excess was associated with a high prevalence of TD in pregnant women, especially TPOAb-positive women (P < 0.05). A logistic regression model based on potential risk factors was established to predict the risk of excessive iodine intake among pregnant women and provide guidance to minimize the risk of excessive iodine intake, thus reducing the risk of TD.https://doi.org/10.1515/biol-2021-0142urinary iodine concentrationpregnant womena logistic regression modelthyroid dysfunction |
| spellingShingle | Zhou Yuhan Chen Fen Wang Lingyu Tian Chunhui Zhang Shuo Ding Feifei Deng Jie Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women Open Life Sciences urinary iodine concentration pregnant women a logistic regression model thyroid dysfunction |
| title | Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women |
| title_full | Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women |
| title_fullStr | Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women |
| title_full_unstemmed | Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women |
| title_short | Establishment of an iodine model for prevention of iodine-excess-induced thyroid dysfunction in pregnant women |
| title_sort | establishment of an iodine model for prevention of iodine excess induced thyroid dysfunction in pregnant women |
| topic | urinary iodine concentration pregnant women a logistic regression model thyroid dysfunction |
| url | https://doi.org/10.1515/biol-2021-0142 |
| work_keys_str_mv | AT zhouyuhan establishmentofaniodinemodelforpreventionofiodineexcessinducedthyroiddysfunctioninpregnantwomen AT chenfen establishmentofaniodinemodelforpreventionofiodineexcessinducedthyroiddysfunctioninpregnantwomen AT wanglingyu establishmentofaniodinemodelforpreventionofiodineexcessinducedthyroiddysfunctioninpregnantwomen AT tianchunhui establishmentofaniodinemodelforpreventionofiodineexcessinducedthyroiddysfunctioninpregnantwomen AT zhangshuo establishmentofaniodinemodelforpreventionofiodineexcessinducedthyroiddysfunctioninpregnantwomen AT dingfeifei establishmentofaniodinemodelforpreventionofiodineexcessinducedthyroiddysfunctioninpregnantwomen AT dengjie establishmentofaniodinemodelforpreventionofiodineexcessinducedthyroiddysfunctioninpregnantwomen |