HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules

HIV-1 Transcription Inhibition Using Small RNA-Binding Molecules

The HIV-1 transactivator protein Tat interacts with the transactivation response element (TAR) at the three-nucleotide UCU bulge to facilitate the recruitment of transcription elongation factor-b (P-TEFb) and induce the transcription of the integrated proviral genome. Therefore, the Tat–TAR interact...

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Bibliographic Details
Main Authors: Pooja Khatkar, Gifty Mensah, Shangbo Ning, Maria Cowen, Yuriy Kim, Anastasia Williams, Fardokht A. Abulwerdi, Yunjie Zhao, Chen Zeng, Stuart F. J. Le Grice, Fatah Kashanchi
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceuticals
Subjects:
HIV-1 transcription
transactivation response element (TAR) RNA
transcription elongation factor-b (P-TEFb)
SWI/SNF complex
molecular modeling
molecular simulation
Online Access:https://www.mdpi.com/1424-8247/17/1/33

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