The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is the main regulator in energy metabolism. Training stimulates many processes like mitochondrial biogenesis, glucose metabolism, and fatty acids metabolism. It also increases the capacity of fat oxidation. The purpose of...
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| Format: | Article |
| Language: | English |
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Ferdowsi University of Mashhad
2020-12-01
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| Series: | The Iranian Journal of Veterinary Science and Technology |
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| Online Access: | https://ijvst.um.ac.ir/article_39718_e979d73178097c06e7c34ead27405184.pdf |
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| author | Keyvan Hejazi Mohammad Mosaferi Ziaaldini, Seyyed Reza Attarzadeh Hosseini Mehrdad Fathi |
| author_facet | Keyvan Hejazi Mohammad Mosaferi Ziaaldini, Seyyed Reza Attarzadeh Hosseini Mehrdad Fathi |
| author_sort | Keyvan Hejazi |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is the main regulator in energy metabolism. Training stimulates many processes like mitochondrial biogenesis, glucose metabolism, and fatty acids metabolism. It also increases the capacity of fat oxidation. The purpose of this study was to investigate the effects of eight-week aerobic training of different intensities on PGC-1α, interferon regulatory factor 4 (IRF4), and atherogenic index in obese male Wistar rats. Twenty-four obese male rats induced by a high-fat diet (weight: 250 to 300 gr, BMI >30g/cm2) were divided into three groups: aerobic training of moderate intensity (MI), aerobic training of high intensity (HI), and the control group (C). The MI and HI training groups carried out exercise training by eight weeks of walking on a treadmill for five sessions/week, 60 min per session, and at a speed of 28 m/min and 34 m/min, respectively. The levels of PGC-1a in the MI and HI groups significantly increased compared to the C group (p < 0.05). Moreover, there was no significant differences between IRF4 levels of MI and HI groups (p > 0.05). The serum HDL-C levels increased only in the MI group compared to the C group (p < 0.05). The LDL-C, TG, TC, and atherogenic index levels reduced more significantly in MI and HI groups than in the C group (p < 0.05). The results show that eight-week aerobic training of two moderate and high intensities may be the signaling pathways to the activation of the PGC-1a protein (i.e., a key regulator of energy metabolism and mitochondrial biogenesis) in skeletal muscle. |
| first_indexed | 2024-12-10T19:31:06Z |
| format | Article |
| id | doaj.art-166542e5d2b64ed6bd0bf12c27e5975e |
| institution | Directory Open Access Journal |
| issn | 2008-465X 2423-6306 |
| language | English |
| last_indexed | 2024-12-10T19:31:06Z |
| publishDate | 2020-12-01 |
| publisher | Ferdowsi University of Mashhad |
| record_format | Article |
| series | The Iranian Journal of Veterinary Science and Technology |
| spelling | doaj.art-166542e5d2b64ed6bd0bf12c27e5975e2022-12-22T01:36:14ZengFerdowsi University of MashhadThe Iranian Journal of Veterinary Science and Technology2008-465X2423-63062020-12-01122505810.22067/ijvst.2021.64211.039718The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar ratsKeyvan Hejazi0Mohammad Mosaferi Ziaaldini,1Seyyed Reza Attarzadeh Hosseini2Mehrdad Fathi3Department of Sport Sciences, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.Department of Sport Sciences, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.Department of exercise physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, IranDepartment of exercise physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is the main regulator in energy metabolism. Training stimulates many processes like mitochondrial biogenesis, glucose metabolism, and fatty acids metabolism. It also increases the capacity of fat oxidation. The purpose of this study was to investigate the effects of eight-week aerobic training of different intensities on PGC-1α, interferon regulatory factor 4 (IRF4), and atherogenic index in obese male Wistar rats. Twenty-four obese male rats induced by a high-fat diet (weight: 250 to 300 gr, BMI >30g/cm2) were divided into three groups: aerobic training of moderate intensity (MI), aerobic training of high intensity (HI), and the control group (C). The MI and HI training groups carried out exercise training by eight weeks of walking on a treadmill for five sessions/week, 60 min per session, and at a speed of 28 m/min and 34 m/min, respectively. The levels of PGC-1a in the MI and HI groups significantly increased compared to the C group (p < 0.05). Moreover, there was no significant differences between IRF4 levels of MI and HI groups (p > 0.05). The serum HDL-C levels increased only in the MI group compared to the C group (p < 0.05). The LDL-C, TG, TC, and atherogenic index levels reduced more significantly in MI and HI groups than in the C group (p < 0.05). The results show that eight-week aerobic training of two moderate and high intensities may be the signaling pathways to the activation of the PGC-1a protein (i.e., a key regulator of energy metabolism and mitochondrial biogenesis) in skeletal muscle.https://ijvst.um.ac.ir/article_39718_e979d73178097c06e7c34ead27405184.pdfaerobic trainingpgc-1αirf4atherogenic index |
| spellingShingle | Keyvan Hejazi Mohammad Mosaferi Ziaaldini, Seyyed Reza Attarzadeh Hosseini Mehrdad Fathi The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats The Iranian Journal of Veterinary Science and Technology aerobic training pgc-1α irf4 atherogenic index |
| title | The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats |
| title_full | The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats |
| title_fullStr | The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats |
| title_full_unstemmed | The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats |
| title_short | The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats |
| title_sort | impact of aerobic training intensity on skeletal muscle pgc 1α interferon regulatory factor 4 and atherogenic index in obese male wistar rats |
| topic | aerobic training pgc-1α irf4 atherogenic index |
| url | https://ijvst.um.ac.ir/article_39718_e979d73178097c06e7c34ead27405184.pdf |
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