Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update
Background: Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is a herbaceous plant used in traditional medicines for the treatment of various ailments. Diterpene lactones are the main phytoconstituents and are responsible for the plant's bitter taste and therapeutic activity. Pure andrograp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031321000671 |
| _version_ | 1818575236458610688 |
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| author | Sharuti Mehta, M. Pharmacy Anil Kumar Sharma, Ph.D. Rajesh K. Singh, Ph.D. |
| author_facet | Sharuti Mehta, M. Pharmacy Anil Kumar Sharma, Ph.D. Rajesh K. Singh, Ph.D. |
| author_sort | Sharuti Mehta, M. Pharmacy |
| collection | DOAJ |
| description | Background: Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is a herbaceous plant used in traditional medicines for the treatment of various ailments. Diterpene lactones are the main phytoconstituents and are responsible for the plant's bitter taste and therapeutic activity. Pure andrographolide (AD) and crude extracts have all been shown to be accountable for various pharmacological activities, including anticancer, anti-inflammatory, hepatoprotective, immunomodulatory, neuroprotective, antidiabetic and antibacterial agents. This review covers recent studies of the exploitation of A. Paniculata with a specific focus on the plant's pharmacological and clinical studies alongwith their therapeutic drug targets and novel drug delivery system. Method: Information for the current review article is collected from various electronic scientific databases such as Science Direct, PubMed, Scopus, Scifinder, Google Scholar, books and reports. All the composed information is classified into different sections according to the objective of the paper. To fetch the useful articles various keywords, namely 'Andrographis paniculata’, ‘King of Bitters’, ‘Andrographolide’ ‘Clinical study’, Molecular mechanism’, ‘Anticancer’, 'Anti-inflammatory', 'Antidiabetic', 'Neuroprotective', ‘Pharmacokinetics’, ‘Novel Drug Delivery System’ were used for search. Results: Of all the 180 studies, twenty one primarily focused on introduction, twenty-seven studies presented a brief introduction of different diseases, ninety studies highlighted the pharmacological activities and therapeutic targets of plant extract and its pure bioactive compounds, twenty five investigations demonstrated the pharmacokinetic parameters of AD and its novel drug delivery systems and seventeen studies investigated clinical studies of the plant. Conclusion: Different recent research and review papers have been studied to gain insights into the therapeutic activities and clinical studies of A. paniculata. Following the extensive literature survey, we collected notable information on the plant. For rapid glance studies, experimental and research findings are compiled into tabular form for quick understanding. Possible directions for future research are also outlined briefly, encouraging the researchers for advance investigations on various mechanistic targets of this plant. |
| first_indexed | 2024-12-15T00:37:30Z |
| format | Article |
| id | doaj.art-1665de6b09e24ad6a5693f5b19ff8ae0 |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-12-15T00:37:30Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-1665de6b09e24ad6a5693f5b19ff8ae02022-12-21T22:41:45ZengElsevierPhytomedicine Plus2667-03132021-11-0114100085Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An updateSharuti Mehta, M. Pharmacy0Anil Kumar Sharma, Ph.D.1Rajesh K. Singh, Ph.D.2CT Institute of Pharmaceutical Sciences, Jalandhar, Punjab 144020, India; Research Scholar at IKG Punjab Technical University, Kapurthala 144601, IndiaAIMIL Pharmaceuticals India Limited, Ranjeet Nagar, New Delhi 110008, IndiaDepartment of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Punjab 140126, India; Corresponding author.Background: Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is a herbaceous plant used in traditional medicines for the treatment of various ailments. Diterpene lactones are the main phytoconstituents and are responsible for the plant's bitter taste and therapeutic activity. Pure andrographolide (AD) and crude extracts have all been shown to be accountable for various pharmacological activities, including anticancer, anti-inflammatory, hepatoprotective, immunomodulatory, neuroprotective, antidiabetic and antibacterial agents. This review covers recent studies of the exploitation of A. Paniculata with a specific focus on the plant's pharmacological and clinical studies alongwith their therapeutic drug targets and novel drug delivery system. Method: Information for the current review article is collected from various electronic scientific databases such as Science Direct, PubMed, Scopus, Scifinder, Google Scholar, books and reports. All the composed information is classified into different sections according to the objective of the paper. To fetch the useful articles various keywords, namely 'Andrographis paniculata’, ‘King of Bitters’, ‘Andrographolide’ ‘Clinical study’, Molecular mechanism’, ‘Anticancer’, 'Anti-inflammatory', 'Antidiabetic', 'Neuroprotective', ‘Pharmacokinetics’, ‘Novel Drug Delivery System’ were used for search. Results: Of all the 180 studies, twenty one primarily focused on introduction, twenty-seven studies presented a brief introduction of different diseases, ninety studies highlighted the pharmacological activities and therapeutic targets of plant extract and its pure bioactive compounds, twenty five investigations demonstrated the pharmacokinetic parameters of AD and its novel drug delivery systems and seventeen studies investigated clinical studies of the plant. Conclusion: Different recent research and review papers have been studied to gain insights into the therapeutic activities and clinical studies of A. paniculata. Following the extensive literature survey, we collected notable information on the plant. For rapid glance studies, experimental and research findings are compiled into tabular form for quick understanding. Possible directions for future research are also outlined briefly, encouraging the researchers for advance investigations on various mechanistic targets of this plant.http://www.sciencedirect.com/science/article/pii/S2667031321000671Andrographis paniculataKalmeghMolecular mechanismPharmacologyHepatoprotectiveAnticancer |
| spellingShingle | Sharuti Mehta, M. Pharmacy Anil Kumar Sharma, Ph.D. Rajesh K. Singh, Ph.D. Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update Phytomedicine Plus Andrographis paniculata Kalmegh Molecular mechanism Pharmacology Hepatoprotective Anticancer |
| title | Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update |
| title_full | Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update |
| title_fullStr | Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update |
| title_full_unstemmed | Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update |
| title_short | Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update |
| title_sort | pharmacological activities and molecular mechanisms of pure and crude extract of andrographis paniculata an update |
| topic | Andrographis paniculata Kalmegh Molecular mechanism Pharmacology Hepatoprotective Anticancer |
| url | http://www.sciencedirect.com/science/article/pii/S2667031321000671 |
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