In silico investigation of heparanase-correlated genes in breast cancer subtypes
ABSTRACT Objective To investigate the possible genes that may be related to the mechanisms that modulate heparanase-1. Methods The analysis was conducted at Universidade Federal de São Paulo, on the data provided by: The Cancer Genome Atlas, University of California Santa Cruz Genome Browser, Ky...
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2020-10-01
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100269&tlng=pt |
| _version_ | 1831810414166409216 |
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| author | Carina Mucciolo Melo Henrique Pereira Prado Gabriela Araújo Attie Daniel Lacaz Ruiz Manoel João Batista Castello Girão Maria Aparecida da Silva Pinhal |
| author_facet | Carina Mucciolo Melo Henrique Pereira Prado Gabriela Araújo Attie Daniel Lacaz Ruiz Manoel João Batista Castello Girão Maria Aparecida da Silva Pinhal |
| author_sort | Carina Mucciolo Melo |
| collection | DOAJ |
| description | ABSTRACT Objective To investigate the possible genes that may be related to the mechanisms that modulate heparanase-1. Methods The analysis was conducted at Universidade Federal de São Paulo, on the data provided by: The Cancer Genome Atlas, University of California Santa Cruz Genome Browser, Kyoto Encyclopedia of Genes and Genomes Pathway Database, Database for Annotation, Visualization and Integrated Discovery Bioinformatics Database and the softwares cBioPortal and Ingenuity Pathway Analysis. Results Using messenger RNA expression pattern of different molecular subtypes of breast cancer, we proposed that heparinase-1 was co-related with its progression. In addition, genes that were analyzed presented co-expression with heparanase-1. The results that showed that heparanase-1 co-expressed with phosphoinositide 3-kinase adapter protein 1, sialic acid-binding immunoglobulin-like lectin 7, and leukocyte-associated immunoglobulin-like receptor 1 are directed related with immune system evasion during breast cancer progression. Furthermore, cathepsin L was co-expressed with heparanase-1 and transformed inactive heparanase-1 form into active heparanase-1, triggering extracellular matrix remodeling, which contributes to enhanced tumor-host interaction of the tumor. Conclusion The signaling pathway analysis using bioinformatics tools gives supporting evidence of possible mechanisms related to breast cancer development. Evasion genes of the immune system co-expressed with heparanase-1, a enzyme related with tumor progression. |
| first_indexed | 2024-12-22T20:58:19Z |
| format | Article |
| id | doaj.art-1668789be01d48e9b255c49c6bac26a2 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-12-22T20:58:19Z |
| publishDate | 2020-10-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-1668789be01d48e9b255c49c6bac26a22022-12-21T18:12:54ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852020-10-011810.31744/einstein_journal/2020ao5447In silico investigation of heparanase-correlated genes in breast cancer subtypesCarina Mucciolo Melohttps://orcid.org/0000-0001-8377-0729Henrique Pereira Pradohttps://orcid.org/0000-0001-5247-5663Gabriela Araújo Attiehttps://orcid.org/0000-0003-3606-8990Daniel Lacaz Ruizhttps://orcid.org/0000-0003-0298-3218Manoel João Batista Castello Girãohttps://orcid.org/0000-0002-1206-9377Maria Aparecida da Silva Pinhalhttps://orcid.org/0000-0003-4001-1663ABSTRACT Objective To investigate the possible genes that may be related to the mechanisms that modulate heparanase-1. Methods The analysis was conducted at Universidade Federal de São Paulo, on the data provided by: The Cancer Genome Atlas, University of California Santa Cruz Genome Browser, Kyoto Encyclopedia of Genes and Genomes Pathway Database, Database for Annotation, Visualization and Integrated Discovery Bioinformatics Database and the softwares cBioPortal and Ingenuity Pathway Analysis. Results Using messenger RNA expression pattern of different molecular subtypes of breast cancer, we proposed that heparinase-1 was co-related with its progression. In addition, genes that were analyzed presented co-expression with heparanase-1. The results that showed that heparanase-1 co-expressed with phosphoinositide 3-kinase adapter protein 1, sialic acid-binding immunoglobulin-like lectin 7, and leukocyte-associated immunoglobulin-like receptor 1 are directed related with immune system evasion during breast cancer progression. Furthermore, cathepsin L was co-expressed with heparanase-1 and transformed inactive heparanase-1 form into active heparanase-1, triggering extracellular matrix remodeling, which contributes to enhanced tumor-host interaction of the tumor. Conclusion The signaling pathway analysis using bioinformatics tools gives supporting evidence of possible mechanisms related to breast cancer development. Evasion genes of the immune system co-expressed with heparanase-1, a enzyme related with tumor progression.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100269&tlng=ptHeparanase-1Computational biologyBreast neoplasms |
| spellingShingle | Carina Mucciolo Melo Henrique Pereira Prado Gabriela Araújo Attie Daniel Lacaz Ruiz Manoel João Batista Castello Girão Maria Aparecida da Silva Pinhal In silico investigation of heparanase-correlated genes in breast cancer subtypes Einstein (São Paulo) Heparanase-1 Computational biology Breast neoplasms |
| title | In silico investigation of heparanase-correlated genes in breast cancer subtypes |
| title_full | In silico investigation of heparanase-correlated genes in breast cancer subtypes |
| title_fullStr | In silico investigation of heparanase-correlated genes in breast cancer subtypes |
| title_full_unstemmed | In silico investigation of heparanase-correlated genes in breast cancer subtypes |
| title_short | In silico investigation of heparanase-correlated genes in breast cancer subtypes |
| title_sort | in silico investigation of heparanase correlated genes in breast cancer subtypes |
| topic | Heparanase-1 Computational biology Breast neoplasms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082020000100269&tlng=pt |
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