Diabetes and Retinal Vascular Dysfunction
Diabetes predominantly affects the microvascular circulation of the retina resulting in a range of structural changes unique to this tissue. These changes ultimately lead to altered permeability, hyperproliferation of endothelial cells and edema, and abnormal vascularization of the retina with resul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Knowledge E
2014-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=3;spage=362;epage=373;aulast=Shin |
| _version_ | 1797990926170193920 |
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| author | Eui Seok Shin Christine M Sorenson Nader Sheibani |
| author_facet | Eui Seok Shin Christine M Sorenson Nader Sheibani |
| author_sort | Eui Seok Shin |
| collection | DOAJ |
| description | Diabetes predominantly affects the microvascular circulation of the retina resulting in a range of structural changes unique to this tissue. These changes ultimately lead to altered permeability, hyperproliferation of endothelial cells and edema, and abnormal vascularization of the retina with resulting loss of vision. Enhanced production of inflammatory mediators and oxidative stress are primary insults with significant contribution to the pathogenesis of diabetic retinopathy (DR). We have determined the identity of the retinal vascular cells affected by hyperglycemia, and have delineated the cell autonomous impact of high glucose on function of these cells. We discuss some of the high glucose specific changes in retinal vascular cells and their contribution to retinal vascular dysfunction. This knowledge provides novel insight into the molecular and cellular defects contributing to the development and progression of diabetic retinopathy, and will aid in the development of innovative, as well as target specific therapeutic approaches for prevention and treatment of DR. |
| first_indexed | 2024-04-11T08:43:52Z |
| format | Article |
| id | doaj.art-16688cd320e747ef882dba4feed91110 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-11T08:43:52Z |
| publishDate | 2014-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-16688cd320e747ef882dba4feed911102022-12-22T04:34:01ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2014-01-019336237310.4103/2008-322X.143378Diabetes and Retinal Vascular DysfunctionEui Seok ShinChristine M SorensonNader SheibaniDiabetes predominantly affects the microvascular circulation of the retina resulting in a range of structural changes unique to this tissue. These changes ultimately lead to altered permeability, hyperproliferation of endothelial cells and edema, and abnormal vascularization of the retina with resulting loss of vision. Enhanced production of inflammatory mediators and oxidative stress are primary insults with significant contribution to the pathogenesis of diabetic retinopathy (DR). We have determined the identity of the retinal vascular cells affected by hyperglycemia, and have delineated the cell autonomous impact of high glucose on function of these cells. We discuss some of the high glucose specific changes in retinal vascular cells and their contribution to retinal vascular dysfunction. This knowledge provides novel insight into the molecular and cellular defects contributing to the development and progression of diabetic retinopathy, and will aid in the development of innovative, as well as target specific therapeutic approaches for prevention and treatment of DR.http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=3;spage=362;epage=373;aulast=ShinDiabetes; Retinal vasculature; Inflammation; Oxidative Stress; Thrombospondins |
| spellingShingle | Eui Seok Shin Christine M Sorenson Nader Sheibani Diabetes and Retinal Vascular Dysfunction Journal of Ophthalmic & Vision Research Diabetes; Retinal vasculature; Inflammation; Oxidative Stress; Thrombospondins |
| title | Diabetes and Retinal Vascular Dysfunction |
| title_full | Diabetes and Retinal Vascular Dysfunction |
| title_fullStr | Diabetes and Retinal Vascular Dysfunction |
| title_full_unstemmed | Diabetes and Retinal Vascular Dysfunction |
| title_short | Diabetes and Retinal Vascular Dysfunction |
| title_sort | diabetes and retinal vascular dysfunction |
| topic | Diabetes; Retinal vasculature; Inflammation; Oxidative Stress; Thrombospondins |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=3;spage=362;epage=373;aulast=Shin |
| work_keys_str_mv | AT euiseokshin diabetesandretinalvasculardysfunction AT christinemsorenson diabetesandretinalvasculardysfunction AT nadersheibani diabetesandretinalvasculardysfunction |