Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study
Getahun B Gemechu,1 Habtemu Hebo,2 Zarihun Kura2 1Ilu Woreda Health Office, Shaggar, Oromia Regional State, Ethiopia; 2Epidemiology Department, Jimma University, Jimma, Oromia Regional State, EthiopiaCorrespondence: Getahun B Gemechu, Email getahunbeyene1@gmail.comBackground: Poor adherence to antir...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-07-01
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| Series: | HIV/AIDS: Research and Palliative Care |
| Subjects: | |
| Online Access: | https://www.dovepress.com/childrens-adherence-to-antiretroviral-therapy-and-associated-factors-m-peer-reviewed-fulltext-article-HIV |
| _version_ | 1797773661314220032 |
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| author | Gemechu GB Hebo H Kura Z |
| author_facet | Gemechu GB Hebo H Kura Z |
| author_sort | Gemechu GB |
| collection | DOAJ |
| description | Getahun B Gemechu,1 Habtemu Hebo,2 Zarihun Kura2 1Ilu Woreda Health Office, Shaggar, Oromia Regional State, Ethiopia; 2Epidemiology Department, Jimma University, Jimma, Oromia Regional State, EthiopiaCorrespondence: Getahun B Gemechu, Email getahunbeyene1@gmail.comBackground: Poor adherence to antiretroviral therapy (ART) causes drug resistance, treatment failure and death. Studies conducted among children below 15 years were limited in Ethiopia in general and in the study area. Therefore, this study aimed to assess the status of children’s adherence to ART and associated factors in the study area.Methods: We conducted a facility-based cross-sectional study from April 1 to May 10, 2020 by including 282 children < 15 years. All children who received ART for at least one month and attend ART clinic during data collection period were consecutively recruited. Face-to-face interview was conducted using a standardized questionnaire. Both bivariate and multivariate logistic regression were performed. Adherence and exposure variables (i.e., sociodemographic and reason for missing) were measured by the caregivers/children’s report of a one-month recall of missed doses.Results: Among 282 caregivers included with their children, 226 (80.2%) were females (mean age = 38.6 and SD = 12.35) and half (50%) of children were females. Two hundred forty six (87.2%) children were aged between 5– 14 years (mean age = 8.5 and SD = 2.64), and 87.2% were adhered (≥ 95%) to ART in the month prior to the interview. Children whose caregivers were residing in urban were 3.3 (95% CI: 1.17, 9.63) times more adherent to ART than their counterparties. Children whose caregivers were biological parents were 2.37 (95% CI: 1.59, 3.3) times more adherent than children with non-biological parents. Children with knowledgeable caregivers about ART were 4.5 (95% CI: 1.79, 9.8) times more adherent to ART.Conclusion and Recommendation: Children’s adherence to ART in our study area was sub optimal. Biological caregivers, residing in urban and being knowledgeable about ART facilitate adherence to ART. Adherence counseling targeting non-biological parents and for those who come from rural areas were recommended.Keywords: adherence, antiretroviral therapy, children, Ethiopia, ART |
| first_indexed | 2024-03-12T22:09:41Z |
| format | Article |
| id | doaj.art-16697f3d395548e999e1942b92ed227e |
| institution | Directory Open Access Journal |
| issn | 1179-1373 |
| language | English |
| last_indexed | 2024-03-12T22:09:41Z |
| publishDate | 2023-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | HIV/AIDS: Research and Palliative Care |
| spelling | doaj.art-16697f3d395548e999e1942b92ed227e2023-07-23T15:49:04ZengDove Medical PressHIV/AIDS: Research and Palliative Care1179-13732023-07-01Volume 1542343485341Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional StudyGemechu GBHebo HKura ZGetahun B Gemechu,1 Habtemu Hebo,2 Zarihun Kura2 1Ilu Woreda Health Office, Shaggar, Oromia Regional State, Ethiopia; 2Epidemiology Department, Jimma University, Jimma, Oromia Regional State, EthiopiaCorrespondence: Getahun B Gemechu, Email getahunbeyene1@gmail.comBackground: Poor adherence to antiretroviral therapy (ART) causes drug resistance, treatment failure and death. Studies conducted among children below 15 years were limited in Ethiopia in general and in the study area. Therefore, this study aimed to assess the status of children’s adherence to ART and associated factors in the study area.Methods: We conducted a facility-based cross-sectional study from April 1 to May 10, 2020 by including 282 children < 15 years. All children who received ART for at least one month and attend ART clinic during data collection period were consecutively recruited. Face-to-face interview was conducted using a standardized questionnaire. Both bivariate and multivariate logistic regression were performed. Adherence and exposure variables (i.e., sociodemographic and reason for missing) were measured by the caregivers/children’s report of a one-month recall of missed doses.Results: Among 282 caregivers included with their children, 226 (80.2%) were females (mean age = 38.6 and SD = 12.35) and half (50%) of children were females. Two hundred forty six (87.2%) children were aged between 5– 14 years (mean age = 8.5 and SD = 2.64), and 87.2% were adhered (≥ 95%) to ART in the month prior to the interview. Children whose caregivers were residing in urban were 3.3 (95% CI: 1.17, 9.63) times more adherent to ART than their counterparties. Children whose caregivers were biological parents were 2.37 (95% CI: 1.59, 3.3) times more adherent than children with non-biological parents. Children with knowledgeable caregivers about ART were 4.5 (95% CI: 1.79, 9.8) times more adherent to ART.Conclusion and Recommendation: Children’s adherence to ART in our study area was sub optimal. Biological caregivers, residing in urban and being knowledgeable about ART facilitate adherence to ART. Adherence counseling targeting non-biological parents and for those who come from rural areas were recommended.Keywords: adherence, antiretroviral therapy, children, Ethiopia, ARThttps://www.dovepress.com/childrens-adherence-to-antiretroviral-therapy-and-associated-factors-m-peer-reviewed-fulltext-article-HIVadherenceantiretroviral therapychildrenethiopia |
| spellingShingle | Gemechu GB Hebo H Kura Z Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study HIV/AIDS: Research and Palliative Care adherence antiretroviral therapy children ethiopia |
| title | Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study |
| title_full | Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study |
| title_fullStr | Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study |
| title_full_unstemmed | Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study |
| title_short | Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study |
| title_sort | children rsquo s adherence to antiretroviral therapy and associated factors multicenter cross sectional study |
| topic | adherence antiretroviral therapy children ethiopia |
| url | https://www.dovepress.com/childrens-adherence-to-antiretroviral-therapy-and-associated-factors-m-peer-reviewed-fulltext-article-HIV |
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