Friend retrovirus infection induces the development of memory-like natural killer cells
Abstract Traditionally, NK cells belong to the innate immune system and eliminate virus-infected cells through their germline-encoded receptors. However, NK cells were recently reported to possess memory-like functions that were predominantly provided by hepatic NK cells. Memory properties were main...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Retrovirology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12977-018-0450-1 |
| _version_ | 1818425848854740992 |
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| author | Elisabeth Littwitz-Salomon Thanh Nguyen Simone Schimmer Ulf Dittmer |
| author_facet | Elisabeth Littwitz-Salomon Thanh Nguyen Simone Schimmer Ulf Dittmer |
| author_sort | Elisabeth Littwitz-Salomon |
| collection | DOAJ |
| description | Abstract Traditionally, NK cells belong to the innate immune system and eliminate virus-infected cells through their germline-encoded receptors. However, NK cells were recently reported to possess memory-like functions that were predominantly provided by hepatic NK cells. Memory properties were mainly documented in contact hypersensitivity models or during cytomegalovirus infections. However, the precise role and the physiologic importance of memory-like NK cells during retroviral infections are still under investigation. Here, we show that Friend retrovirus (FV) infection of mice induced a population of phenotypically memory-like NK cells at 28 days post infection. Upon secondary antigen encounter, these NK cells showed an increased production of the pro-inflammatory cytokines IFNγ and TNFα as well as the death ligand FasL in comparison to naïve NK cells. Furthermore, we found an augmented elimination of antigen-matched but not antigen-mismatched target cells by these memory-like NK cells. In adoptive cell transfer experiments, equal antiviral activities of splenic and hepatic memory-like NK cells during the late phase of acute FV infection were found. Our results strongly imply the existence and antiviral activity of spleen and liver memory-like NK cells in FV infection, which efficiently respond upon secondary exposure to retroviral antigens. |
| first_indexed | 2024-12-14T14:20:28Z |
| format | Article |
| id | doaj.art-166a1733b9c64bc1891e9997e207ee84 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-12-14T14:20:28Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-166a1733b9c64bc1891e9997e207ee842022-12-21T22:58:05ZengBMCRetrovirology1742-46902018-10-0115111010.1186/s12977-018-0450-1Friend retrovirus infection induces the development of memory-like natural killer cellsElisabeth Littwitz-Salomon0Thanh Nguyen1Simone Schimmer2Ulf Dittmer3Institute for Virology, University Hospital Essen, University of Duisburg-EssenUniversity of Duisburg-EssenInstitute for Virology, University Hospital Essen, University of Duisburg-EssenInstitute for Virology, University Hospital Essen, University of Duisburg-EssenAbstract Traditionally, NK cells belong to the innate immune system and eliminate virus-infected cells through their germline-encoded receptors. However, NK cells were recently reported to possess memory-like functions that were predominantly provided by hepatic NK cells. Memory properties were mainly documented in contact hypersensitivity models or during cytomegalovirus infections. However, the precise role and the physiologic importance of memory-like NK cells during retroviral infections are still under investigation. Here, we show that Friend retrovirus (FV) infection of mice induced a population of phenotypically memory-like NK cells at 28 days post infection. Upon secondary antigen encounter, these NK cells showed an increased production of the pro-inflammatory cytokines IFNγ and TNFα as well as the death ligand FasL in comparison to naïve NK cells. Furthermore, we found an augmented elimination of antigen-matched but not antigen-mismatched target cells by these memory-like NK cells. In adoptive cell transfer experiments, equal antiviral activities of splenic and hepatic memory-like NK cells during the late phase of acute FV infection were found. Our results strongly imply the existence and antiviral activity of spleen and liver memory-like NK cells in FV infection, which efficiently respond upon secondary exposure to retroviral antigens.http://link.springer.com/article/10.1186/s12977-018-0450-1Natural killer cellsImmunological memoryFriend virusRetrovirusMemory NK cellsAntigen specificity |
| spellingShingle | Elisabeth Littwitz-Salomon Thanh Nguyen Simone Schimmer Ulf Dittmer Friend retrovirus infection induces the development of memory-like natural killer cells Retrovirology Natural killer cells Immunological memory Friend virus Retrovirus Memory NK cells Antigen specificity |
| title | Friend retrovirus infection induces the development of memory-like natural killer cells |
| title_full | Friend retrovirus infection induces the development of memory-like natural killer cells |
| title_fullStr | Friend retrovirus infection induces the development of memory-like natural killer cells |
| title_full_unstemmed | Friend retrovirus infection induces the development of memory-like natural killer cells |
| title_short | Friend retrovirus infection induces the development of memory-like natural killer cells |
| title_sort | friend retrovirus infection induces the development of memory like natural killer cells |
| topic | Natural killer cells Immunological memory Friend virus Retrovirus Memory NK cells Antigen specificity |
| url | http://link.springer.com/article/10.1186/s12977-018-0450-1 |
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