Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis

The significance of the osteogenesis-angiogenesis relationship in the healing process of bone defects has been increasingly emphasized in recent academic research. Surface topography plays a crucial role in guiding cellular behaviors. Metal-organic framework (MOF) is an innovative biomaterial with n...

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Main Authors: Leyi Liu, Jie Wu, Shiyu Lv, Duoling Xu, Shujun Li, Wentao Hou, Chao Wang, Dongsheng Yu
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Materials Today Bio
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423003265
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author Leyi Liu
Jie Wu
Shiyu Lv
Duoling Xu
Shujun Li
Wentao Hou
Chao Wang
Dongsheng Yu
author_facet Leyi Liu
Jie Wu
Shiyu Lv
Duoling Xu
Shujun Li
Wentao Hou
Chao Wang
Dongsheng Yu
author_sort Leyi Liu
collection DOAJ
description The significance of the osteogenesis-angiogenesis relationship in the healing process of bone defects has been increasingly emphasized in recent academic research. Surface topography plays a crucial role in guiding cellular behaviors. Metal-organic framework (MOF) is an innovative biomaterial with nanoscale structural and topological features, enabling the modulation of scaffold physicochemical properties. This study involved the loading of varying quantities of UiO-66 nanocrystals onto alkali-heat treated 3D-printed titanium scaffolds, resulting in the formation of hierarchical micro/nano topography named UiO-66/AHTs. The physicochemical properties of these scaffolds were subsequently characterized. Furthermore, the impact of these scaffolds on the osteogenic potential of BMSCs, the angiogenic potential of HUVECs, and their intercellular communication were investigated. The findings of this study indicated that 1/2UiO-66/AHT outperformed other groups in terms of osteogenic and angiogenic induction, as well as in promoting intercellular crosstalk by enhancing paracrine effects. These results suggest a promising biomimetic hierarchical topography design that facilitates the coupling of osteogenesis and angiogenesis.
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spelling doaj.art-166b0448718c4624b21c709a3c0aa61d2023-12-07T05:30:03ZengElsevierMaterials Today Bio2590-00642023-12-0123100866Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesisLeyi Liu0Jie Wu1Shiyu Lv2Duoling Xu3Shujun Li4Wentao Hou5Chao Wang6Dongsheng Yu7Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055, ChinaHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055, ChinaHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055, ChinaHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055, ChinaInstitute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, ChinaInstitute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, ChinaHospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China; Corresponding author. Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China.Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China; Corresponding author. Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China.The significance of the osteogenesis-angiogenesis relationship in the healing process of bone defects has been increasingly emphasized in recent academic research. Surface topography plays a crucial role in guiding cellular behaviors. Metal-organic framework (MOF) is an innovative biomaterial with nanoscale structural and topological features, enabling the modulation of scaffold physicochemical properties. This study involved the loading of varying quantities of UiO-66 nanocrystals onto alkali-heat treated 3D-printed titanium scaffolds, resulting in the formation of hierarchical micro/nano topography named UiO-66/AHTs. The physicochemical properties of these scaffolds were subsequently characterized. Furthermore, the impact of these scaffolds on the osteogenic potential of BMSCs, the angiogenic potential of HUVECs, and their intercellular communication were investigated. The findings of this study indicated that 1/2UiO-66/AHT outperformed other groups in terms of osteogenic and angiogenic induction, as well as in promoting intercellular crosstalk by enhancing paracrine effects. These results suggest a promising biomimetic hierarchical topography design that facilitates the coupling of osteogenesis and angiogenesis.http://www.sciencedirect.com/science/article/pii/S2590006423003265Hierarchical topographyUiO-66Coupling of osteogenesis and angiogenesis
spellingShingle Leyi Liu
Jie Wu
Shiyu Lv
Duoling Xu
Shujun Li
Wentao Hou
Chao Wang
Dongsheng Yu
Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
Materials Today Bio
Hierarchical topography
UiO-66
Coupling of osteogenesis and angiogenesis
title Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
title_full Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
title_fullStr Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
title_full_unstemmed Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
title_short Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
title_sort synergistic effect of hierarchical topographic structure on 3d printed titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
topic Hierarchical topography
UiO-66
Coupling of osteogenesis and angiogenesis
url http://www.sciencedirect.com/science/article/pii/S2590006423003265
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