Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation

Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation

Ca2+ and Vm transitions occurring throughout action potential (AP) cycles in sinoatrial nodal (SAN) cells are cues that (1) not only regulate activation states of molecules operating within criticality (Ca2+ domain) and limit-cycle (Vm domain) mechanisms of a coupled-clock system that underlies SAN...

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Main Authors: Dongmei Yang, Christopher H. Morrell, Alexey E. Lyashkov, Syevda Tagirova Sirenko, Ihor Zahanich, Yael Yaniv, Tatiana M. Vinogradova, Bruce D. Ziman, Victor A. Maltsev, Edward G. Lakatta
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
single sinoatrial nodal pacemaker cells
local diastolic Ca2+ releases
diastolic depolarization
autonomic receptor stimulation
self-similarity of Ca2+ and membrane potential during action potentials
action potential
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.612770/full

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