Dopant-Dependent Toxicity of CeO<sub>2</sub> Nanoparticles Is Associated with Dynamic Changes in H3K4me3 and H3K27me3 and Transcriptional Activation of NRF2 Gene in HaCaT Human Keratinocytes

Dopant-Dependent Toxicity of CeO<sub>2</sub> Nanoparticles Is Associated with Dynamic Changes in H3K4me3 and H3K27me3 and Transcriptional Activation of NRF2 Gene in HaCaT Human Keratinocytes

Despite advances in the preparation of metal oxide (MO) nanoparticles (NPs) as catalysts for various applications, concerns about the biosafety of these particles remain. In this study, we prepared transition metal-doped cerium oxide (TM@CeO<sub>2</sub>; TM = Cr, Mn, Fe, Co, or Ni) nanop...

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Bibliographic Details
Main Authors: Jang Hyun Choi, Haram Lee, Hangil Lee, Hansol Lee
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
cerium oxide nanoparticles (CeO<sub>2</sub> NPs)
transition metal doping
reactive oxygen species (ROS)
NRF2-KEAP1 pathway
histone lysine methylation
Online Access:https://www.mdpi.com/1422-0067/22/6/3087

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https://www.mdpi.com/1422-0067/22/6/3087

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