Brazilian embauba () extract reduces renal lesions in 5/6 nephrectomized rats
Introduction: Cecropia pachystachya (CP) is a plant rich in polyphenols which inhibits the angiotensin-converting enzyme (ACE) in vitro. Angiotensin II (AII) has an important role in the renal lesion provoked by 5/6 nephrectomy (NE). This study evaluated the CP extract effect on renal lesions provok...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2014-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320313501219 |
| _version_ | 1797284130687287296 |
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| author | Claudia do C Maquiaveli Edson R da Silva Heloísa DC Francescato Roberto S Costa Cleonice GA Silva Dulce E Casarini Fernanda A Ronchi Terezila M Coimbra |
| author_facet | Claudia do C Maquiaveli Edson R da Silva Heloísa DC Francescato Roberto S Costa Cleonice GA Silva Dulce E Casarini Fernanda A Ronchi Terezila M Coimbra |
| author_sort | Claudia do C Maquiaveli |
| collection | DOAJ |
| description | Introduction: Cecropia pachystachya (CP) is a plant rich in polyphenols which inhibits the angiotensin-converting enzyme (ACE) in vitro. Angiotensin II (AII) has an important role in the renal lesion provoked by 5/6 nephrectomy (NE). This study evaluated the CP extract effect on renal lesions provoked by 5/6 NE. Materials and methods: Male Wistar rats submitted to 5/6 NE were treated or not treated with CP extract and followed for 90 days. Systemic blood pressure (SBP), albuminuria, renal functional and structural parameters, ACE activity, urinary levels of monocyte chemoattrant protein-1 (MCP-1) and transforming growth factor β (TGF-β) were evaluated. Results: Albuminuria and hypertension were less intense in the treated (NE+CP) group compared to the untreated (NE) group. CP extract treatment reduced the fall in glomerular filtration rate observed in NE rats. Glomerulosclerosis, tubulointerstitial lesions, increase of macrophages and AII positive cells in the renal cortex, as well as increases in renal ACE activity, urinary levels of MCP-1 and TGF-β were attenuated in NE rats by CP treatment. Conclusions: The treatment with CP extract reduced the SBP and functional and structural renal changes in 5/6 NE rats. These effects were associated with decreased AII expression, ACE activity and inflammation in the renal cortex. |
| first_indexed | 2024-03-07T17:44:31Z |
| format | Article |
| id | doaj.art-167262a291e34f3aa7ffbd8771909a43 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:44:31Z |
| publishDate | 2014-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-167262a291e34f3aa7ffbd8771909a432024-03-02T15:18:51ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762014-12-011510.1177/1470320313501219Brazilian embauba () extract reduces renal lesions in 5/6 nephrectomized ratsClaudia do C Maquiaveli0Edson R da Silva1Heloísa DC Francescato2Roberto S Costa3Cleonice GA Silva4Dulce E Casarini5Fernanda A Ronchi6Terezila M Coimbra7Department of Physiology, University of São Paulo, BrazilDepartment of Veterinary Medicine, University of São Paulo, BrazilDepartment of Physiology, University of São Paulo, BrazilDepartment of Pathology, University of São Paulo, BrazilDepartment of Physiology, University of São Paulo, BrazilDepartment of Medicine, Federal University of São Paulo, BrazilDepartment of Medicine, Federal University of São Paulo, BrazilDepartment of Physiology, University of São Paulo, BrazilIntroduction: Cecropia pachystachya (CP) is a plant rich in polyphenols which inhibits the angiotensin-converting enzyme (ACE) in vitro. Angiotensin II (AII) has an important role in the renal lesion provoked by 5/6 nephrectomy (NE). This study evaluated the CP extract effect on renal lesions provoked by 5/6 NE. Materials and methods: Male Wistar rats submitted to 5/6 NE were treated or not treated with CP extract and followed for 90 days. Systemic blood pressure (SBP), albuminuria, renal functional and structural parameters, ACE activity, urinary levels of monocyte chemoattrant protein-1 (MCP-1) and transforming growth factor β (TGF-β) were evaluated. Results: Albuminuria and hypertension were less intense in the treated (NE+CP) group compared to the untreated (NE) group. CP extract treatment reduced the fall in glomerular filtration rate observed in NE rats. Glomerulosclerosis, tubulointerstitial lesions, increase of macrophages and AII positive cells in the renal cortex, as well as increases in renal ACE activity, urinary levels of MCP-1 and TGF-β were attenuated in NE rats by CP treatment. Conclusions: The treatment with CP extract reduced the SBP and functional and structural renal changes in 5/6 NE rats. These effects were associated with decreased AII expression, ACE activity and inflammation in the renal cortex.https://doi.org/10.1177/1470320313501219 |
| spellingShingle | Claudia do C Maquiaveli Edson R da Silva Heloísa DC Francescato Roberto S Costa Cleonice GA Silva Dulce E Casarini Fernanda A Ronchi Terezila M Coimbra Brazilian embauba () extract reduces renal lesions in 5/6 nephrectomized rats Journal of the Renin-Angiotensin-Aldosterone System |
| title | Brazilian embauba () extract reduces renal lesions in 5/6 nephrectomized rats |
| title_full | Brazilian embauba () extract reduces renal lesions in 5/6 nephrectomized rats |
| title_fullStr | Brazilian embauba () extract reduces renal lesions in 5/6 nephrectomized rats |
| title_full_unstemmed | Brazilian embauba () extract reduces renal lesions in 5/6 nephrectomized rats |
| title_short | Brazilian embauba () extract reduces renal lesions in 5/6 nephrectomized rats |
| title_sort | brazilian embauba extract reduces renal lesions in 5 6 nephrectomized rats |
| url | https://doi.org/10.1177/1470320313501219 |
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