The nociceptin receptor promotes autophagy through NF-kB signaling and is transcriptionally regulated by E2F1 in HCC

The nociceptin receptor promotes autophagy through NF-kB signaling and is transcriptionally regulated by E2F1 in HCC

Abstract Opioids and their receptors are involved in cancer progression. However, the roles of the nociceptin receptor (NOP) and its antagonist (JTC801) in hepatocellular carcinoma (HCC) are poorly understood. The prognostic value of NOP expression was evaluated using tissue microarray and immunohis...

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Bibliographic Details
Main Authors: Xiaoshuang Zhou, Dongtai Chen, Yan Yan, Qiang Li, Wei Xing, Yanling Liu, Yonghua Chen, Dongyin Wang, Yunfei Yuan, Jingdun Xie, Weian Zeng, Jiahao Pan
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00978-7

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