Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection
Muluneh Ademe Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Muluneh Ademe Email muluneh.ademe@aau.edu.etAbstract: Myeloid-derived suppressor cells (MDSCs) are heterogeneous groups of pathologically ac...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-04-01
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| Series: | HIV/AIDS: Research and Palliative Care |
| Subjects: | |
| Online Access: | https://www.dovepress.com/paradoxes-in-the-phenotype-frequency-and-roles-of-myeloid-derived-supp-peer-reviewed-article-HIV |
| _version_ | 1818343524605624320 |
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| author | Ademe M |
| author_facet | Ademe M |
| author_sort | Ademe M |
| collection | DOAJ |
| description | Muluneh Ademe Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Muluneh Ademe Email muluneh.ademe@aau.edu.etAbstract: Myeloid-derived suppressor cells (MDSCs) are heterogeneous groups of pathologically activated myeloid cells with potent immunosuppressive function. Due to their role in negatively regulating the immune system, MDSCs have been strongly correlated with disease progression during HIV. However, findings vary considerably between studies. The dominant phenotype of MDSC subsets during HIV is not well ascertained. Moreover, there is no clear understanding on the clinical significance of MDSCs during HIV infection. The existing evidences showed the double-sided roles of MDSCs in HIV. On the one hand, MDSCs are linked to deleterious effects during HIV infection as they inhibit proliferation of protective T cell response. On the other hand, the immunosuppressive abilities of MDSCs were shown to be beneficial in curbing the damaging effects of persistent immune activation associated with chronic HIV infection. Therefore, this review aimed to describe the differences in the existing literatures pertaining to the phenotype, frequency and roles of MDSCs during HIV infection.Keywords: MDSCs, phenotype, HIV, ART, therapeutic targets, paradox |
| first_indexed | 2024-12-13T16:31:57Z |
| format | Article |
| id | doaj.art-1672dbde12ed46078e79b496ba1394ad |
| institution | Directory Open Access Journal |
| issn | 1179-1373 |
| language | English |
| last_indexed | 2024-12-13T16:31:57Z |
| publishDate | 2020-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | HIV/AIDS: Research and Palliative Care |
| spelling | doaj.art-1672dbde12ed46078e79b496ba1394ad2022-12-21T23:38:28ZengDove Medical PressHIV/AIDS: Research and Palliative Care1179-13732020-04-01Volume 1215115653054Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV InfectionAdeme MMuluneh Ademe Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Muluneh Ademe Email muluneh.ademe@aau.edu.etAbstract: Myeloid-derived suppressor cells (MDSCs) are heterogeneous groups of pathologically activated myeloid cells with potent immunosuppressive function. Due to their role in negatively regulating the immune system, MDSCs have been strongly correlated with disease progression during HIV. However, findings vary considerably between studies. The dominant phenotype of MDSC subsets during HIV is not well ascertained. Moreover, there is no clear understanding on the clinical significance of MDSCs during HIV infection. The existing evidences showed the double-sided roles of MDSCs in HIV. On the one hand, MDSCs are linked to deleterious effects during HIV infection as they inhibit proliferation of protective T cell response. On the other hand, the immunosuppressive abilities of MDSCs were shown to be beneficial in curbing the damaging effects of persistent immune activation associated with chronic HIV infection. Therefore, this review aimed to describe the differences in the existing literatures pertaining to the phenotype, frequency and roles of MDSCs during HIV infection.Keywords: MDSCs, phenotype, HIV, ART, therapeutic targets, paradoxhttps://www.dovepress.com/paradoxes-in-the-phenotype-frequency-and-roles-of-myeloid-derived-supp-peer-reviewed-article-HIVmdscsphenotypehivarttherapeutic targetsparadox |
| spellingShingle | Ademe M Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection HIV/AIDS: Research and Palliative Care mdscs phenotype hiv art therapeutic targets paradox |
| title | Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection |
| title_full | Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection |
| title_fullStr | Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection |
| title_full_unstemmed | Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection |
| title_short | Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection |
| title_sort | paradoxes in the phenotype frequency and roles of myeloid derived suppressor cells during hiv infection |
| topic | mdscs phenotype hiv art therapeutic targets paradox |
| url | https://www.dovepress.com/paradoxes-in-the-phenotype-frequency-and-roles-of-myeloid-derived-supp-peer-reviewed-article-HIV |
| work_keys_str_mv | AT ademem paradoxesinthephenotypefrequencyandrolesofmyeloidderivedsuppressorcellsduringhivinfection |