Engineering of lysin by fusion of antimicrobial peptide (cecropin A) enhances its antibacterial properties against multidrug-resistant Acinetobacter baumannii

Engineering of lysin by fusion of antimicrobial peptide (cecropin A) enhances its antibacterial properties against multidrug-resistant Acinetobacter baumannii

Most clinical isolates of Acinetobacter baumannii, a nosocomial pathogen, are multidrug-resistant (MDR), fueling the search for alternative therapies. Bacteriophage-derived endolysins have potent antibacterial activities and are considered as alternatives to antibiotics against A. baumannii infectio...

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Bibliographic Details
Main Authors: Md Maidul Islam, Dooyoung Kim, Kyeongmin Kim, Su-Jin Park, Samia Akter, Jeongah Kim, Seunghyeok Bang, Shukho Kim, Jungmin Kim, Je Chul Lee, Chang-Won Hong, Minsang Shin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Microbiology
Subjects:
Acinetobacter baumannii
cecropin A
endolysin
antibacterial activity
synergistic effect
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.988522/full

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