Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge
Abstract Isolated central nervous system lymphomatoid granulomatosis (CNS‐LYG) can mimic aggressive glioblastomas. We describe a complex presentation of CNS‐LYG coexisting with immune thrombocytopenia successfully managed with rituximab and ultra‐low‐dose radiation therapy.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-09-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.4808 |
| _version_ | 1818887980805259264 |
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| author | Mohsin Soleja Jesse Manuel Jaso Weina Chen Jack Raisanen Christian A. Wysocki Yu‐Min Shen Bruce Mickey Kiran A. Kumar Praveen Ramakrishnan Geethakumari |
| author_facet | Mohsin Soleja Jesse Manuel Jaso Weina Chen Jack Raisanen Christian A. Wysocki Yu‐Min Shen Bruce Mickey Kiran A. Kumar Praveen Ramakrishnan Geethakumari |
| author_sort | Mohsin Soleja |
| collection | DOAJ |
| description | Abstract Isolated central nervous system lymphomatoid granulomatosis (CNS‐LYG) can mimic aggressive glioblastomas. We describe a complex presentation of CNS‐LYG coexisting with immune thrombocytopenia successfully managed with rituximab and ultra‐low‐dose radiation therapy. |
| first_indexed | 2024-12-19T16:45:51Z |
| format | Article |
| id | doaj.art-1673a2faf2d849e6976966fea289a728 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-12-19T16:45:51Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-1673a2faf2d849e6976966fea289a7282022-12-21T20:13:39ZengWileyClinical Case Reports2050-09042021-09-0199n/an/a10.1002/ccr3.4808Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challengeMohsin Soleja0Jesse Manuel Jaso1Weina Chen2Jack Raisanen3Christian A. Wysocki4Yu‐Min Shen5Bruce Mickey6Kiran A. Kumar7Praveen Ramakrishnan Geethakumari8Division of Hematologic Malignancies and Cellular Therapy, Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center UT Southwestern Medical Center Dallas TX USADepartment of Pathology Harold. C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX USADepartment of Pathology Harold. C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX USADepartment of Pathology Harold. C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX USADivision of Allergy and Immunology, Department of Internal Medicine UT Southwestern Medical Center Dallas TX USADivision of Hematologic Malignancies and Cellular Therapy, Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center UT Southwestern Medical Center Dallas TX USADepartment of Neurosurgery Harold. C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX USADepartment of Radiation Oncology Harold. C. Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center Dallas TX USADivision of Hematologic Malignancies and Cellular Therapy, Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center UT Southwestern Medical Center Dallas TX USAAbstract Isolated central nervous system lymphomatoid granulomatosis (CNS‐LYG) can mimic aggressive glioblastomas. We describe a complex presentation of CNS‐LYG coexisting with immune thrombocytopenia successfully managed with rituximab and ultra‐low‐dose radiation therapy.https://doi.org/10.1002/ccr3.4808EBV‐associated B‐cell lymphoproliferative disorderEpstein‐Barr virusimmune thrombocytopenialymphomatoid granulomatosispulmonary embolismthrombosis |
| spellingShingle | Mohsin Soleja Jesse Manuel Jaso Weina Chen Jack Raisanen Christian A. Wysocki Yu‐Min Shen Bruce Mickey Kiran A. Kumar Praveen Ramakrishnan Geethakumari Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge Clinical Case Reports EBV‐associated B‐cell lymphoproliferative disorder Epstein‐Barr virus immune thrombocytopenia lymphomatoid granulomatosis pulmonary embolism thrombosis |
| title | Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge |
| title_full | Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge |
| title_fullStr | Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge |
| title_full_unstemmed | Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge |
| title_short | Lymphomatoid granulomatosis of the central nervous system (CNS‐LYG) posing a management challenge |
| title_sort | lymphomatoid granulomatosis of the central nervous system cns lyg posing a management challenge |
| topic | EBV‐associated B‐cell lymphoproliferative disorder Epstein‐Barr virus immune thrombocytopenia lymphomatoid granulomatosis pulmonary embolism thrombosis |
| url | https://doi.org/10.1002/ccr3.4808 |
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