Impact of Stereotactic Body Radiotherapy on Thrombin Generation and Platelet Aggregation in Patients with Non-Small Cell Lung Cancer
Patients with localized non-small cell lung cancer (NSCLC) considered unfit for surgery are at substantially increased risk of venous thromboembolism. Radiotherapy may further increase this risk. We aim to investigate the impact of stereotactic body radiotherapy (SBRT) on thrombin generation and pla...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-11-01
|
| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296231216962 |
| _version_ | 1797449540680286208 |
|---|---|
| author | Kristian Kirkelund Bentsen MD Johanne Andersen Hojbjerg MD, PhD Pernille Just Vinholt MD, PhD Olfred Hansen MD, PhD Anne-Mette Hvas MD, PhD Stefan Starup Jeppesen MD, PhD |
| author_facet | Kristian Kirkelund Bentsen MD Johanne Andersen Hojbjerg MD, PhD Pernille Just Vinholt MD, PhD Olfred Hansen MD, PhD Anne-Mette Hvas MD, PhD Stefan Starup Jeppesen MD, PhD |
| author_sort | Kristian Kirkelund Bentsen MD |
| collection | DOAJ |
| description | Patients with localized non-small cell lung cancer (NSCLC) considered unfit for surgery are at substantially increased risk of venous thromboembolism. Radiotherapy may further increase this risk. We aim to investigate the impact of stereotactic body radiotherapy (SBRT) on thrombin generation and platelet aggregation. We included 110 patients with localized NSCLC treated with SBRT. Blood samples were obtained prior to SBRT, immediately after SBRT completion, and 4-6 weeks following SBRT. Ex vivo and in vivo thrombin generations were analyzed using a calibrated automated thrombogram and commercial enzyme-linked immunosorbent assays. Platelet aggregation was evaluated using multiple electrode aggregometry. No significant differences were found in ex vivo or in vivo thrombin generation between blood samples before and immediately after SBRT treatment. Platelet aggregation was lower immediately after SBRT than before SBRT (TRAP: P = 0.04 and ASPI: P = 0.02) but remained within the reference interval. SBRT did not affect in vivo and ex vivo thrombin generation or platelet aggregation. SBRT did not cause prothrombotic changes in the coagulation in this study population of SBRT-treated patients with localized NSCLC. |
| first_indexed | 2024-03-09T14:26:28Z |
| format | Article |
| id | doaj.art-1676742dee2c4b64bb6aec97b99f8e03 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-03-09T14:26:28Z |
| publishDate | 2023-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-1676742dee2c4b64bb6aec97b99f8e032023-11-28T07:03:33ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232023-11-012910.1177/10760296231216962Impact of Stereotactic Body Radiotherapy on Thrombin Generation and Platelet Aggregation in Patients with Non-Small Cell Lung CancerKristian Kirkelund Bentsen MD0Johanne Andersen Hojbjerg MD, PhD1Pernille Just Vinholt MD, PhD2Olfred Hansen MD, PhD3Anne-Mette Hvas MD, PhD4Stefan Starup Jeppesen MD, PhD5 Academy of Geriatric Cancer Research (AgeCare), , Odense, Denmark Department of Clinical Medicine, , Aarhus, Denmark Department of Clinical Biochemistry, , Odense, Denmark Academy of Geriatric Cancer Research (AgeCare), , Odense, Denmark Department of Clinical Medicine, , Aarhus, Denmark Academy of Geriatric Cancer Research (AgeCare), , Odense, DenmarkPatients with localized non-small cell lung cancer (NSCLC) considered unfit for surgery are at substantially increased risk of venous thromboembolism. Radiotherapy may further increase this risk. We aim to investigate the impact of stereotactic body radiotherapy (SBRT) on thrombin generation and platelet aggregation. We included 110 patients with localized NSCLC treated with SBRT. Blood samples were obtained prior to SBRT, immediately after SBRT completion, and 4-6 weeks following SBRT. Ex vivo and in vivo thrombin generations were analyzed using a calibrated automated thrombogram and commercial enzyme-linked immunosorbent assays. Platelet aggregation was evaluated using multiple electrode aggregometry. No significant differences were found in ex vivo or in vivo thrombin generation between blood samples before and immediately after SBRT treatment. Platelet aggregation was lower immediately after SBRT than before SBRT (TRAP: P = 0.04 and ASPI: P = 0.02) but remained within the reference interval. SBRT did not affect in vivo and ex vivo thrombin generation or platelet aggregation. SBRT did not cause prothrombotic changes in the coagulation in this study population of SBRT-treated patients with localized NSCLC.https://doi.org/10.1177/10760296231216962 |
| spellingShingle | Kristian Kirkelund Bentsen MD Johanne Andersen Hojbjerg MD, PhD Pernille Just Vinholt MD, PhD Olfred Hansen MD, PhD Anne-Mette Hvas MD, PhD Stefan Starup Jeppesen MD, PhD Impact of Stereotactic Body Radiotherapy on Thrombin Generation and Platelet Aggregation in Patients with Non-Small Cell Lung Cancer Clinical and Applied Thrombosis/Hemostasis |
| title | Impact of Stereotactic Body Radiotherapy on Thrombin Generation and Platelet Aggregation in Patients with Non-Small Cell Lung Cancer |
| title_full | Impact of Stereotactic Body Radiotherapy on Thrombin Generation and Platelet Aggregation in Patients with Non-Small Cell Lung Cancer |
| title_fullStr | Impact of Stereotactic Body Radiotherapy on Thrombin Generation and Platelet Aggregation in Patients with Non-Small Cell Lung Cancer |
| title_full_unstemmed | Impact of Stereotactic Body Radiotherapy on Thrombin Generation and Platelet Aggregation in Patients with Non-Small Cell Lung Cancer |
| title_short | Impact of Stereotactic Body Radiotherapy on Thrombin Generation and Platelet Aggregation in Patients with Non-Small Cell Lung Cancer |
| title_sort | impact of stereotactic body radiotherapy on thrombin generation and platelet aggregation in patients with non small cell lung cancer |
| url | https://doi.org/10.1177/10760296231216962 |
| work_keys_str_mv | AT kristiankirkelundbentsenmd impactofstereotacticbodyradiotherapyonthrombingenerationandplateletaggregationinpatientswithnonsmallcelllungcancer AT johanneandersenhojbjergmdphd impactofstereotacticbodyradiotherapyonthrombingenerationandplateletaggregationinpatientswithnonsmallcelllungcancer AT pernillejustvinholtmdphd impactofstereotacticbodyradiotherapyonthrombingenerationandplateletaggregationinpatientswithnonsmallcelllungcancer AT olfredhansenmdphd impactofstereotacticbodyradiotherapyonthrombingenerationandplateletaggregationinpatientswithnonsmallcelllungcancer AT annemettehvasmdphd impactofstereotacticbodyradiotherapyonthrombingenerationandplateletaggregationinpatientswithnonsmallcelllungcancer AT stefanstarupjeppesenmdphd impactofstereotacticbodyradiotherapyonthrombingenerationandplateletaggregationinpatientswithnonsmallcelllungcancer |