Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis
BackgroundNumerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.MethodsPubMed, Embase, and Cochrane Li...
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| Format: | Article |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1315097/full |
| _version_ | 1797362375895023616 |
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| author | Lei Zhong Jifeng Liu Mingquan Xia Yunshu Zhang Shuo Liu Guang Tan |
| author_facet | Lei Zhong Jifeng Liu Mingquan Xia Yunshu Zhang Shuo Liu Guang Tan |
| author_sort | Lei Zhong |
| collection | DOAJ |
| description | BackgroundNumerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.MethodsPubMed, Embase, and Cochrane Library were searched for studies that examined the association between sarcopenia and survival after pancreatic surgery from the inception of the database until June 1, 2023. Hazard ratio (HR) for overall survival (OS) and/or progression-free survival (PFS) of sarcopenia and pancreatic surgery were extracted from the selected studies and random or fixed-effect models were used to summarize the data according to the heterogeneity. Publication bias was assessed using Egger’s linear regression test and a funnel plot.ResultsSixteen studies met the inclusion criteria. For 13 aggregated univariate and 16 multivariate estimates, sarcopenia was associated with decreased OS (univariate analysis: HR 1.69, 95% CI 1.48–1.93; multivariate analysis: HR 1.69; 95% CI 1.39–2.05, I2 = 77.4%). Furthermore, sarcopenia was significantly associated with poor PFS of pancreatic resection (Change to univariate analysis: HR 1.74, 95% CI 1.47–2.05; multivariate analysis: HR 1.54; 95% CI 1.23–1.93, I2 = 63%).ConclusionSarcopenia may be a significant prognostic factor for a shortened survival following pancreatectomy since it is linked to an elevated risk of mortality. Further studies are required to understand how sarcopenia affects long-term results after pancreatic resection.Systematic review registrationRegistration ID: CRD42023438208 https://www.crd.york.ac.uk/PROSPERO/#recordDetails. |
| first_indexed | 2024-03-08T16:07:07Z |
| format | Article |
| id | doaj.art-1676f631049b4d5b9e3ec9b421175c65 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-08T16:07:07Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-1676f631049b4d5b9e3ec9b421175c652024-01-08T05:05:23ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-01-011010.3389/fnut.2023.13150971315097Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysisLei Zhong0Jifeng Liu1Mingquan Xia2Yunshu Zhang3Shuo Liu4Guang Tan5Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaBackgroundNumerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.MethodsPubMed, Embase, and Cochrane Library were searched for studies that examined the association between sarcopenia and survival after pancreatic surgery from the inception of the database until June 1, 2023. Hazard ratio (HR) for overall survival (OS) and/or progression-free survival (PFS) of sarcopenia and pancreatic surgery were extracted from the selected studies and random or fixed-effect models were used to summarize the data according to the heterogeneity. Publication bias was assessed using Egger’s linear regression test and a funnel plot.ResultsSixteen studies met the inclusion criteria. For 13 aggregated univariate and 16 multivariate estimates, sarcopenia was associated with decreased OS (univariate analysis: HR 1.69, 95% CI 1.48–1.93; multivariate analysis: HR 1.69; 95% CI 1.39–2.05, I2 = 77.4%). Furthermore, sarcopenia was significantly associated with poor PFS of pancreatic resection (Change to univariate analysis: HR 1.74, 95% CI 1.47–2.05; multivariate analysis: HR 1.54; 95% CI 1.23–1.93, I2 = 63%).ConclusionSarcopenia may be a significant prognostic factor for a shortened survival following pancreatectomy since it is linked to an elevated risk of mortality. Further studies are required to understand how sarcopenia affects long-term results after pancreatic resection.Systematic review registrationRegistration ID: CRD42023438208 https://www.crd.york.ac.uk/PROSPERO/#recordDetails.https://www.frontiersin.org/articles/10.3389/fnut.2023.1315097/fullsarcopeniapancreatectomysurvivalcancermeta-analysis |
| spellingShingle | Lei Zhong Jifeng Liu Mingquan Xia Yunshu Zhang Shuo Liu Guang Tan Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis Frontiers in Nutrition sarcopenia pancreatectomy survival cancer meta-analysis |
| title | Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis |
| title_full | Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis |
| title_fullStr | Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis |
| title_short | Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis |
| title_sort | effect of sarcopenia on survival in patients after pancreatic surgery a systematic review and meta analysis |
| topic | sarcopenia pancreatectomy survival cancer meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1315097/full |
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