Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes
Objective: Leptin plays a pathophysiologic role in the pathogenesis of aortic dysfunction and peripheral arterial stiffness (PAS). Our aim was to evaluate the risk factors for developing PAS and the association of leptin and PAS in patients with type 2 diabetes mellitus (DM). Materials and Methods:...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Tzu-Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2018;volume=30;issue=1;spage=10;epage=14;aulast=Lu |
| _version_ | 1828903500730335232 |
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| author | Chia-Wen Lu Chung-Jen Lee Jia-Sian Hou Du-An Wu Bang-Gee Hsu |
| author_facet | Chia-Wen Lu Chung-Jen Lee Jia-Sian Hou Du-An Wu Bang-Gee Hsu |
| author_sort | Chia-Wen Lu |
| collection | DOAJ |
| description | Objective: Leptin plays a pathophysiologic role in the pathogenesis of aortic dysfunction and peripheral arterial stiffness (PAS). Our aim was to evaluate the risk factors for developing PAS and the association of leptin and PAS in patients with type 2 diabetes mellitus (DM). Materials and Methods: Fasting blood samples were obtained for biochemical data and leptin determinations from 105 patients with type 2 DM. In this study, we applied an automatic pulse wave analyzer (VaSera VS-1000) to measure the brachial-ankle pulse wave velocity (baPWV); a baPWV value >14.0 m/s on either side was considered high PAS. Results: Seventy-five patients (71.4%) had high PAS and they included a higher percentage of patients with hypertension (P < 0.001), older age (P < 0.001), and a higher body fat mass (P = 0.043), systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.016), serum blood urea nitrogen (P = 0.003), and leptin level (P < 0.001), and lower height (P = 0.027) and glomerular filtration rate (P < 0.001) compared with type 2 DM patients with low PAS. After adjusting for factors significantly associated with PAS in these patients by multivariate logistic regression analysis, age (β = 0.470, adjusted R2 change = 0.279; P < 0.001), logarithmically transformed leptin (log-leptin, β = 0.259, adjusted R2 change = 0.085; P = 0.001), and hypertension (β = 0.197, adjusted R2 change = 0.031; P = 0.011) were significant independent predictors of PAS in type 2 DM patients. Conclusion: The serum leptin level could be a predictor of PAS in type 2 DM patients. |
| first_indexed | 2024-12-13T16:34:30Z |
| format | Article |
| id | doaj.art-167afaca56af40d3a57f37677ac61e53 |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-12-13T16:34:30Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-167afaca56af40d3a57f37677ac61e532022-12-21T23:38:25ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562018-01-01301101410.4103/tcmj.tcmj_183_17Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetesChia-Wen LuChung-Jen LeeJia-Sian HouDu-An WuBang-Gee HsuObjective: Leptin plays a pathophysiologic role in the pathogenesis of aortic dysfunction and peripheral arterial stiffness (PAS). Our aim was to evaluate the risk factors for developing PAS and the association of leptin and PAS in patients with type 2 diabetes mellitus (DM). Materials and Methods: Fasting blood samples were obtained for biochemical data and leptin determinations from 105 patients with type 2 DM. In this study, we applied an automatic pulse wave analyzer (VaSera VS-1000) to measure the brachial-ankle pulse wave velocity (baPWV); a baPWV value >14.0 m/s on either side was considered high PAS. Results: Seventy-five patients (71.4%) had high PAS and they included a higher percentage of patients with hypertension (P < 0.001), older age (P < 0.001), and a higher body fat mass (P = 0.043), systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.016), serum blood urea nitrogen (P = 0.003), and leptin level (P < 0.001), and lower height (P = 0.027) and glomerular filtration rate (P < 0.001) compared with type 2 DM patients with low PAS. After adjusting for factors significantly associated with PAS in these patients by multivariate logistic regression analysis, age (β = 0.470, adjusted R2 change = 0.279; P < 0.001), logarithmically transformed leptin (log-leptin, β = 0.259, adjusted R2 change = 0.085; P = 0.001), and hypertension (β = 0.197, adjusted R2 change = 0.031; P = 0.011) were significant independent predictors of PAS in type 2 DM patients. Conclusion: The serum leptin level could be a predictor of PAS in type 2 DM patients.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2018;volume=30;issue=1;spage=10;epage=14;aulast=LuBrachial-ankle pulse wave velocityLeptinPeripheral arterial stiffnessType 2 diabetes mellitus |
| spellingShingle | Chia-Wen Lu Chung-Jen Lee Jia-Sian Hou Du-An Wu Bang-Gee Hsu Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes Tzu-Chi Medical Journal Brachial-ankle pulse wave velocity Leptin Peripheral arterial stiffness Type 2 diabetes mellitus |
| title | Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes |
| title_full | Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes |
| title_fullStr | Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes |
| title_full_unstemmed | Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes |
| title_short | Positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes |
| title_sort | positive correlation of serum leptin levels and peripheral arterial stiffness in patients with type 2 diabetes |
| topic | Brachial-ankle pulse wave velocity Leptin Peripheral arterial stiffness Type 2 diabetes mellitus |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2018;volume=30;issue=1;spage=10;epage=14;aulast=Lu |
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