Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-X<sub>L</sub>

Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-X<sub>L</sub>

<p>Abstract</p> <p>Background</p> <p>Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observe...

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Bibliographic Details
Main Authors:	Hastie C James, McLauchlan Hilary, Toth Rachel, Campbell David G, Macdonald Andrew, Arthur J Simon C
Format:	Article
Language:	English
Published:	BMC 2006-01-01
Series:	BMC Cell Biology
Online Access:	http://www.biomedcentral.com/1471-2121/7/1

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