Interaction between the 5-HT system and the basal ganglia: Functional implication and therapeutic perspective in Parkinson’s disease
The neurotransmitter serotonin (5-HT) has a multifaceted function in the modulation of information processing through the activation of multiple receptor families, including G-protein-coupled receptor subtypes (5-HT1, 5-HT2, 5-HT4-7) and ligand-gated ion channels (5-HT3). The largest population of s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-03-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00021/full |
| _version_ | 1828532087154540544 |
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| author | Cristina eMiguelez Teresa eMorera-Herreras Maria eTorrecilla Jose Angel eRuiz-Ortega Luisa eUgedo |
| author_facet | Cristina eMiguelez Teresa eMorera-Herreras Maria eTorrecilla Jose Angel eRuiz-Ortega Luisa eUgedo |
| author_sort | Cristina eMiguelez |
| collection | DOAJ |
| description | The neurotransmitter serotonin (5-HT) has a multifaceted function in the modulation of information processing through the activation of multiple receptor families, including G-protein-coupled receptor subtypes (5-HT1, 5-HT2, 5-HT4-7) and ligand-gated ion channels (5-HT3). The largest population of serotonergic neurons is located in the midbrain, specifically in the raphe nuclei. Although the medial and dorsal raphe nucleus (DRN) share common projecting areas, in the basal ganglia (BG) nuclei serotonergic innervations come mainly from the DRN. The BG are a highly organized network of subcortical nuclei composed of the striatum (caudate and putamen), subthalamic nucleus (STN), internal and external globus pallidus (or entopeduncular nucleus in rodents, GPi/EP and GPe) and substantia nigra (pars compacta, SNc, and pars reticulata, SNr). The BG are part of the cortico-BG-thalamic circuits, which play a role in many functions like motor control, emotion, and cognition and are critically involved in diseases such as Parkinson’s disease. <br/>This review provides an overview of serotonergic modulation of the BG at the functional level and a discussion of how this interaction may be relevant to treating Parkinson’s disease and the motor complications induced by chronic treatment with L-DOPA. <br/> |
| first_indexed | 2024-12-11T22:48:09Z |
| format | Article |
| id | doaj.art-167c575c4e494cbfad2952e8b3fb6a1a |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-11T22:48:09Z |
| publishDate | 2014-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-167c575c4e494cbfad2952e8b3fb6a1a2022-12-22T00:47:33ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102014-03-01810.3389/fncir.2014.0002181195Interaction between the 5-HT system and the basal ganglia: Functional implication and therapeutic perspective in Parkinson’s diseaseCristina eMiguelez0Teresa eMorera-Herreras1Maria eTorrecilla2Jose Angel eRuiz-Ortega3Luisa eUgedo4University of the Basque Country, UPV/EHUUniversity of the Basque Country, UPV/EHUUniversity of the Basque Country, UPV/EHUUniversity of the Basque Country, UPV/EHUUniversity of the Basque Country, UPV/EHUThe neurotransmitter serotonin (5-HT) has a multifaceted function in the modulation of information processing through the activation of multiple receptor families, including G-protein-coupled receptor subtypes (5-HT1, 5-HT2, 5-HT4-7) and ligand-gated ion channels (5-HT3). The largest population of serotonergic neurons is located in the midbrain, specifically in the raphe nuclei. Although the medial and dorsal raphe nucleus (DRN) share common projecting areas, in the basal ganglia (BG) nuclei serotonergic innervations come mainly from the DRN. The BG are a highly organized network of subcortical nuclei composed of the striatum (caudate and putamen), subthalamic nucleus (STN), internal and external globus pallidus (or entopeduncular nucleus in rodents, GPi/EP and GPe) and substantia nigra (pars compacta, SNc, and pars reticulata, SNr). The BG are part of the cortico-BG-thalamic circuits, which play a role in many functions like motor control, emotion, and cognition and are critically involved in diseases such as Parkinson’s disease. <br/>This review provides an overview of serotonergic modulation of the BG at the functional level and a discussion of how this interaction may be relevant to treating Parkinson’s disease and the motor complications induced by chronic treatment with L-DOPA. <br/>http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00021/fullBasal GangliaElectrophysiologyParkinson’s disease5-HTL-DOPA induced dyskinesia |
| spellingShingle | Cristina eMiguelez Teresa eMorera-Herreras Maria eTorrecilla Jose Angel eRuiz-Ortega Luisa eUgedo Interaction between the 5-HT system and the basal ganglia: Functional implication and therapeutic perspective in Parkinson’s disease Frontiers in Neural Circuits Basal Ganglia Electrophysiology Parkinson’s disease 5-HT L-DOPA induced dyskinesia |
| title | Interaction between the 5-HT system and the basal ganglia: Functional implication and therapeutic perspective in Parkinson’s disease |
| title_full | Interaction between the 5-HT system and the basal ganglia: Functional implication and therapeutic perspective in Parkinson’s disease |
| title_fullStr | Interaction between the 5-HT system and the basal ganglia: Functional implication and therapeutic perspective in Parkinson’s disease |
| title_full_unstemmed | Interaction between the 5-HT system and the basal ganglia: Functional implication and therapeutic perspective in Parkinson’s disease |
| title_short | Interaction between the 5-HT system and the basal ganglia: Functional implication and therapeutic perspective in Parkinson’s disease |
| title_sort | interaction between the 5 ht system and the basal ganglia functional implication and therapeutic perspective in parkinson s disease |
| topic | Basal Ganglia Electrophysiology Parkinson’s disease 5-HT L-DOPA induced dyskinesia |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2014.00021/full |
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