The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site

The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site

Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic spindle are well-known and effective chemotherapeutic agents. These agents interrupt the microtubule network via polymerization or depolymerization, halting the cell cycle progression and leading to apoptosis. W...

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Bibliographic Details
Main Authors: Sergei Boichuk, Aigul Galembikova, Kirill Syuzov, Pavel Dunaev, Firuza Bikinieva, Aida Aukhadieva, Svetlana Zykova, Nazim Igidov, Ksenia Gankova, Maria Novikova, Pavel Kopnin
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
microtubules
tubulin depolymerization
cell cycle
mitotic arrest
apoptosis
breast
Online Access:https://www.mdpi.com/1420-3049/26/19/5780

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https://www.mdpi.com/1420-3049/26/19/5780

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