Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population
Abstract Background: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. Methods: Be...
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| Format: | Article |
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Tehran University of Medical Sciences
2021-10-01
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| Series: | Iranian Journal of Public Health |
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| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/25429 |
| _version_ | 1818405889607991296 |
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| author | Min Mu Li Jing Yuan-Jie Zou Xing-Rong Tao Fei Wang Jun Lu |
| author_facet | Min Mu Li Jing Yuan-Jie Zou Xing-Rong Tao Fei Wang Jun Lu |
| author_sort | Min Mu |
| collection | DOAJ |
| description | Abstract
Background: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown.
Methods: Between January 2016 and November 2018, a hospital-based case-control study was conducted. This epidemiological survey was conducted in both hospitals every three months. rs3798719, rs1570069, and rs2236212 in ELOVL2 gene were detected by Sanger sequencing.
Results: Stratified by gender, the genotypes and allele frequencies of rs3798719, rs1570069 and rs2236212 showed significant differences between the two groups (χ2 = 6.987, P = 0.030), Genetic modeling showed that rs3798719 was statistically different in the overdominance model (χ2 = 4.784, OR = 1.414, 95% CI: 1.036-1.929, P < 0.05). The polymorphism of rs2236212 between male TB patients and healthy controls was statistically different in the dominance model. (χ2 = 4.192, OR = 0.507; 95% CI: 0.262-0.981, P < 0.05).
Conclusion: The rs3798719 of ELOVL2 gene may be associated with susceptibility to TB in female population and the rs2236212 of ELOVL2 gene may be associated with TB incidence in male patients. |
| first_indexed | 2024-12-14T09:03:13Z |
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| id | doaj.art-167c9c0891a048698b52f73846265190 |
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| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-14T09:03:13Z |
| publishDate | 2021-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-167c9c0891a048698b52f738462651902022-12-21T23:08:46ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932021-10-015011Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han PopulationMin Mu0Li Jing1Yuan-Jie Zou2Xing-Rong Tao3Fei Wang4Jun Lu51. Key Laboratory, Industrial Dust Control and Occupational Health, The Ministry of Education, Anhui University of Science and Technology , Anhui, China 2. Department of Medical frontier Experimental Center, School of Medicine, Anhui University of Science and Technology, Anhui, China 3. Key Laboratory, Industrial Dust Deep Reduction and Occupational Health and Safety, Anhui Higher Education Institutes, An-hui University of Science and Technology, Anhui, ChinaDepartment of Medical frontier Experimental Center, School of Medicine, Anhui University of Science and Technology, Anhui, ChinaDepartment of Medical frontier Experimental Center, School of Medicine, Anhui University of Science and Technology, Anhui, China1. Key Laboratory, Industrial Dust Control and Occupational Health, The Ministry of Education, Anhui University of Science and Technology , Anhui, China 2. Department of Medical frontier Experimental Center, School of Medicine, Anhui University of Science and Technology, Anhui, China 3. Key Laboratory, Industrial Dust Deep Reduction and Occupational Health and Safety, Anhui Higher Education Institutes, An-hui University of Science and Technology, Anhui, China1. Key Laboratory, Industrial Dust Control and Occupational Health, The Ministry of Education, Anhui University of Science and Technology , Anhui, China 2. Department of Medical frontier Experimental Center, School of Medicine, Anhui University of Science and Technology, Anhui, China 3. Key Laboratory, Industrial Dust Deep Reduction and Occupational Health and Safety, Anhui Higher Education Institutes, An-hui University of Science and Technology, Anhui, China1. Key Laboratory, Industrial Dust Control and Occupational Health, The Ministry of Education, Anhui University of Science and Technology , Anhui, China 2. Department of Medical frontier Experimental Center, School of Medicine, Anhui University of Science and Technology, Anhui, China 3. Key Laboratory, Industrial Dust Deep Reduction and Occupational Health and Safety, Anhui Higher Education Institutes, An-hui University of Science and Technology, Anhui, ChinaAbstract Background: As an infectious disease closely related to Mycobacterium tuberculosis, autoimmunity, inflammation, environment and heredity, the relationship between the single nucleotide polymorphism of elongase 2 gene and the susceptibility to tuberculosis is still unknown. Methods: Between January 2016 and November 2018, a hospital-based case-control study was conducted. This epidemiological survey was conducted in both hospitals every three months. rs3798719, rs1570069, and rs2236212 in ELOVL2 gene were detected by Sanger sequencing. Results: Stratified by gender, the genotypes and allele frequencies of rs3798719, rs1570069 and rs2236212 showed significant differences between the two groups (χ2 = 6.987, P = 0.030), Genetic modeling showed that rs3798719 was statistically different in the overdominance model (χ2 = 4.784, OR = 1.414, 95% CI: 1.036-1.929, P < 0.05). The polymorphism of rs2236212 between male TB patients and healthy controls was statistically different in the dominance model. (χ2 = 4.192, OR = 0.507; 95% CI: 0.262-0.981, P < 0.05). Conclusion: The rs3798719 of ELOVL2 gene may be associated with susceptibility to TB in female population and the rs2236212 of ELOVL2 gene may be associated with TB incidence in male patients.https://ijph.tums.ac.ir/index.php/ijph/article/view/25429Tuberculosis; ELOVL2 geneSingle nucleotide polymorphismChina |
| spellingShingle | Min Mu Li Jing Yuan-Jie Zou Xing-Rong Tao Fei Wang Jun Lu Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population Iranian Journal of Public Health Tuberculosis; ELOVL2 gene Single nucleotide polymorphism China |
| title | Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population |
| title_full | Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population |
| title_fullStr | Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population |
| title_full_unstemmed | Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population |
| title_short | Polymorphisms of Fatty Acid Elongase 2 Gene Afftects Risk of Pulmonary Tuberculosis in China Han Population |
| title_sort | polymorphisms of fatty acid elongase 2 gene afftects risk of pulmonary tuberculosis in china han population |
| topic | Tuberculosis; ELOVL2 gene Single nucleotide polymorphism China |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/25429 |
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