New Insights into the Role of Histone Changes in Aging
Aging is the progressive decline or loss of function at the cellular, tissue, and organismal levels that ultimately leads to death. A number of external and internal factors, including diet, exercise, metabolic dysfunction, genome instability, and epigenetic imbalance, affect the lifespan of an orga...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8241 |
| _version_ | 1797548857377161216 |
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| author | Sun-Ju Yi Kyunghwan Kim |
| author_facet | Sun-Ju Yi Kyunghwan Kim |
| author_sort | Sun-Ju Yi |
| collection | DOAJ |
| description | Aging is the progressive decline or loss of function at the cellular, tissue, and organismal levels that ultimately leads to death. A number of external and internal factors, including diet, exercise, metabolic dysfunction, genome instability, and epigenetic imbalance, affect the lifespan of an organism. These aging factors regulate transcriptome changes related to the aging process through chromatin remodeling. Many epigenetic regulators, such as histone modification, histone variants, and ATP-dependent chromatin remodeling factors, play roles in chromatin reorganization. The key to understanding the role of gene regulatory networks in aging lies in characterizing the epigenetic regulators responsible for reorganizing and potentiating particular chromatin structures. This review covers epigenetic studies on aging, discusses the impact of epigenetic modifications on gene expression, and provides future directions in this area. |
| first_indexed | 2024-03-10T15:06:45Z |
| format | Article |
| id | doaj.art-167dcc60f386421988a0cfca6d8a0ad5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:06:45Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-167dcc60f386421988a0cfca6d8a0ad52023-11-20T19:41:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012121824110.3390/ijms21218241New Insights into the Role of Histone Changes in AgingSun-Ju Yi0Kyunghwan Kim1Department of Biology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Chungbuk, KoreaDepartment of Biology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Chungbuk, KoreaAging is the progressive decline or loss of function at the cellular, tissue, and organismal levels that ultimately leads to death. A number of external and internal factors, including diet, exercise, metabolic dysfunction, genome instability, and epigenetic imbalance, affect the lifespan of an organism. These aging factors regulate transcriptome changes related to the aging process through chromatin remodeling. Many epigenetic regulators, such as histone modification, histone variants, and ATP-dependent chromatin remodeling factors, play roles in chromatin reorganization. The key to understanding the role of gene regulatory networks in aging lies in characterizing the epigenetic regulators responsible for reorganizing and potentiating particular chromatin structures. This review covers epigenetic studies on aging, discusses the impact of epigenetic modifications on gene expression, and provides future directions in this area.https://www.mdpi.com/1422-0067/21/21/8241aginghistone levelhistone modificationhistone variantchromatin remodelingepigenetics |
| spellingShingle | Sun-Ju Yi Kyunghwan Kim New Insights into the Role of Histone Changes in Aging International Journal of Molecular Sciences aging histone level histone modification histone variant chromatin remodeling epigenetics |
| title | New Insights into the Role of Histone Changes in Aging |
| title_full | New Insights into the Role of Histone Changes in Aging |
| title_fullStr | New Insights into the Role of Histone Changes in Aging |
| title_full_unstemmed | New Insights into the Role of Histone Changes in Aging |
| title_short | New Insights into the Role of Histone Changes in Aging |
| title_sort | new insights into the role of histone changes in aging |
| topic | aging histone level histone modification histone variant chromatin remodeling epigenetics |
| url | https://www.mdpi.com/1422-0067/21/21/8241 |
| work_keys_str_mv | AT sunjuyi newinsightsintotheroleofhistonechangesinaging AT kyunghwankim newinsightsintotheroleofhistonechangesinaging |