Neutrophil extracellular traps and neutrophilic dermatosis: an update review
Abstract Neutrophils have both antimicrobial ability and pathogenic effect in the immune system, neutrophil extracellular traps (NETs) formation is one of the representative behaviors of their dual role. NETs formation was triggered by pathogen-related components and pathogen non-related proteins as...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-01-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01787-2 |
| _version_ | 1827382387815743488 |
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| author | Sheng Li Shuni Ying Yuqian Wang Yelu Lv Jianjun Qiao Hong Fang |
| author_facet | Sheng Li Shuni Ying Yuqian Wang Yelu Lv Jianjun Qiao Hong Fang |
| author_sort | Sheng Li |
| collection | DOAJ |
| description | Abstract Neutrophils have both antimicrobial ability and pathogenic effect in the immune system, neutrophil extracellular traps (NETs) formation is one of the representative behaviors of their dual role. NETs formation was triggered by pathogen-related components and pathogen non-related proteins as cytokines to exert its effector functions. Recent studies indicate that the pathogenicity of NETs contributed to several skin diseases such as psoriasis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and neutrophilic dermatosis. Especially in neutrophilic dermatosis, a heterogeneous group of inflammatory skin disorders characterized with sterile neutrophilic infiltrate on dermis, NETs formation was reported as the way of participation of neutrophils in the pathogenesis of these diseases. In this review, we describe the different processes of NETs formation, then summarized the most recent updates about the pathogenesis of neutrophilic dermatosis and the participation of NETs, including pyoderma gangrenosum and PAPA syndrome, Behçet syndrome, hidradenitis suppurativa, Sweet Syndrome, pustular dermatosis and other neutrophilic dermatosis. Furthermore, we discuss the link between NETs formation and the development of neutrophilic dermatosis. |
| first_indexed | 2024-03-08T14:18:50Z |
| format | Article |
| id | doaj.art-167f88828f7f49eba9d60c85341fa72b |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-03-08T14:18:50Z |
| publishDate | 2024-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-167f88828f7f49eba9d60c85341fa72b2024-01-14T12:12:09ZengNature Publishing GroupCell Death Discovery2058-77162024-01-011011610.1038/s41420-023-01787-2Neutrophil extracellular traps and neutrophilic dermatosis: an update reviewSheng Li0Shuni Ying1Yuqian Wang2Yelu Lv3Jianjun Qiao4Hong Fang5Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Dermatology, The First Affiliated Hospital, Zhejiang University School of MedicineAbstract Neutrophils have both antimicrobial ability and pathogenic effect in the immune system, neutrophil extracellular traps (NETs) formation is one of the representative behaviors of their dual role. NETs formation was triggered by pathogen-related components and pathogen non-related proteins as cytokines to exert its effector functions. Recent studies indicate that the pathogenicity of NETs contributed to several skin diseases such as psoriasis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and neutrophilic dermatosis. Especially in neutrophilic dermatosis, a heterogeneous group of inflammatory skin disorders characterized with sterile neutrophilic infiltrate on dermis, NETs formation was reported as the way of participation of neutrophils in the pathogenesis of these diseases. In this review, we describe the different processes of NETs formation, then summarized the most recent updates about the pathogenesis of neutrophilic dermatosis and the participation of NETs, including pyoderma gangrenosum and PAPA syndrome, Behçet syndrome, hidradenitis suppurativa, Sweet Syndrome, pustular dermatosis and other neutrophilic dermatosis. Furthermore, we discuss the link between NETs formation and the development of neutrophilic dermatosis.https://doi.org/10.1038/s41420-023-01787-2 |
| spellingShingle | Sheng Li Shuni Ying Yuqian Wang Yelu Lv Jianjun Qiao Hong Fang Neutrophil extracellular traps and neutrophilic dermatosis: an update review Cell Death Discovery |
| title | Neutrophil extracellular traps and neutrophilic dermatosis: an update review |
| title_full | Neutrophil extracellular traps and neutrophilic dermatosis: an update review |
| title_fullStr | Neutrophil extracellular traps and neutrophilic dermatosis: an update review |
| title_full_unstemmed | Neutrophil extracellular traps and neutrophilic dermatosis: an update review |
| title_short | Neutrophil extracellular traps and neutrophilic dermatosis: an update review |
| title_sort | neutrophil extracellular traps and neutrophilic dermatosis an update review |
| url | https://doi.org/10.1038/s41420-023-01787-2 |
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