Contribution of viral and bacterial infections to senescence and immunosenescence
Cellular senescence is a key biological process characterized by irreversible cell cycle arrest. The accumulation of senescent cells creates a pro-inflammatory environment that can negatively affect tissue functions and may promote the development of aging-related diseases. Typical biomarkers relate...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1229098/full |
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| author | Antonia Reyes Antonia Reyes Gerardo Ortiz Gerardo Ortiz Luisa F. Duarte Luisa F. Duarte Luisa F. Duarte Christian Fernández Christian Fernández Rosario Hernández-Armengol Rosario Hernández-Armengol Pablo A. Palacios Pablo A. Palacios Yolanda Prado Yolanda Prado Catalina A. Andrade Catalina A. Andrade Linmar Rodriguez-Guilarte Linmar Rodriguez-Guilarte Alexis M. Kalergis Alexis M. Kalergis Alexis M. Kalergis Felipe Simon Felipe Simon Leandro J. Carreño Leandro J. Carreño Claudia A. Riedel Claudia A. Riedel Mónica Cáceres Mónica Cáceres Pablo A. González Pablo A. González |
| author_facet | Antonia Reyes Antonia Reyes Gerardo Ortiz Gerardo Ortiz Luisa F. Duarte Luisa F. Duarte Luisa F. Duarte Christian Fernández Christian Fernández Rosario Hernández-Armengol Rosario Hernández-Armengol Pablo A. Palacios Pablo A. Palacios Yolanda Prado Yolanda Prado Catalina A. Andrade Catalina A. Andrade Linmar Rodriguez-Guilarte Linmar Rodriguez-Guilarte Alexis M. Kalergis Alexis M. Kalergis Alexis M. Kalergis Felipe Simon Felipe Simon Leandro J. Carreño Leandro J. Carreño Claudia A. Riedel Claudia A. Riedel Mónica Cáceres Mónica Cáceres Pablo A. González Pablo A. González |
| author_sort | Antonia Reyes |
| collection | DOAJ |
| description | Cellular senescence is a key biological process characterized by irreversible cell cycle arrest. The accumulation of senescent cells creates a pro-inflammatory environment that can negatively affect tissue functions and may promote the development of aging-related diseases. Typical biomarkers related to senescence include senescence-associated β-galactosidase activity, histone H2A.X phosphorylation at serine139 (γH2A.X), and senescence-associated heterochromatin foci (SAHF) with heterochromatin protein 1γ (HP-1γ protein) Moreover, immune cells undergoing senescence, which is known as immunosenescence, can affect innate and adaptative immune functions and may elicit detrimental effects over the host’s susceptibility to infectious diseases. Although associations between senescence and pathogens have been reported, clear links between both, and the related molecular mechanisms involved remain to be determined. Furthermore, it remains to be determined whether infections effectively induce senescence, the impact of senescence and immunosenescence over infections, or if both events coincidently share common molecular markers, such as γH2A.X and p53. Here, we review and discuss the most recent reports that describe cellular hallmarks and biomarkers related to senescence in immune and non-immune cells in the context of infections, seeking to better understand their relationships. Related literature was searched in Pubmed and Google Scholar databases with search terms related to the sections and subsections of this review. |
| first_indexed | 2024-03-12T01:34:49Z |
| format | Article |
| id | doaj.art-1681f6a753494ad19037c099d29646e8 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-12T01:34:49Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-1681f6a753494ad19037c099d29646e82023-09-11T07:02:39ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-09-011310.3389/fcimb.2023.12290981229098Contribution of viral and bacterial infections to senescence and immunosenescenceAntonia Reyes0Antonia Reyes1Gerardo Ortiz2Gerardo Ortiz3Luisa F. Duarte4Luisa F. Duarte5Luisa F. Duarte6Christian Fernández7Christian Fernández8Rosario Hernández-Armengol9Rosario Hernández-Armengol10Pablo A. Palacios11Pablo A. Palacios12Yolanda Prado13Yolanda Prado14Catalina A. Andrade15Catalina A. Andrade16Linmar Rodriguez-Guilarte17Linmar Rodriguez-Guilarte18Alexis M. Kalergis19Alexis M. Kalergis20Alexis M. Kalergis21Felipe Simon22Felipe Simon23Leandro J. Carreño24Leandro J. Carreño25Claudia A. Riedel26Claudia A. Riedel27Mónica Cáceres28Mónica Cáceres29Pablo A. González30Pablo A. González31Millennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileFacultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChilePrograma de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChilePrograma de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Santiago, ChileMillennium Institute on Immunology and Immunotherapy, Santiago, ChileFacultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, ChileCellular senescence is a key biological process characterized by irreversible cell cycle arrest. The accumulation of senescent cells creates a pro-inflammatory environment that can negatively affect tissue functions and may promote the development of aging-related diseases. Typical biomarkers related to senescence include senescence-associated β-galactosidase activity, histone H2A.X phosphorylation at serine139 (γH2A.X), and senescence-associated heterochromatin foci (SAHF) with heterochromatin protein 1γ (HP-1γ protein) Moreover, immune cells undergoing senescence, which is known as immunosenescence, can affect innate and adaptative immune functions and may elicit detrimental effects over the host’s susceptibility to infectious diseases. Although associations between senescence and pathogens have been reported, clear links between both, and the related molecular mechanisms involved remain to be determined. Furthermore, it remains to be determined whether infections effectively induce senescence, the impact of senescence and immunosenescence over infections, or if both events coincidently share common molecular markers, such as γH2A.X and p53. Here, we review and discuss the most recent reports that describe cellular hallmarks and biomarkers related to senescence in immune and non-immune cells in the context of infections, seeking to better understand their relationships. Related literature was searched in Pubmed and Google Scholar databases with search terms related to the sections and subsections of this review.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1229098/fullsenescenceimmunosenescencechronic infectionspersistent infectionsvirusbacteria |
| spellingShingle | Antonia Reyes Antonia Reyes Gerardo Ortiz Gerardo Ortiz Luisa F. Duarte Luisa F. Duarte Luisa F. Duarte Christian Fernández Christian Fernández Rosario Hernández-Armengol Rosario Hernández-Armengol Pablo A. Palacios Pablo A. Palacios Yolanda Prado Yolanda Prado Catalina A. Andrade Catalina A. Andrade Linmar Rodriguez-Guilarte Linmar Rodriguez-Guilarte Alexis M. Kalergis Alexis M. Kalergis Alexis M. Kalergis Felipe Simon Felipe Simon Leandro J. Carreño Leandro J. Carreño Claudia A. Riedel Claudia A. Riedel Mónica Cáceres Mónica Cáceres Pablo A. González Pablo A. González Contribution of viral and bacterial infections to senescence and immunosenescence Frontiers in Cellular and Infection Microbiology senescence immunosenescence chronic infections persistent infections virus bacteria |
| title | Contribution of viral and bacterial infections to senescence and immunosenescence |
| title_full | Contribution of viral and bacterial infections to senescence and immunosenescence |
| title_fullStr | Contribution of viral and bacterial infections to senescence and immunosenescence |
| title_full_unstemmed | Contribution of viral and bacterial infections to senescence and immunosenescence |
| title_short | Contribution of viral and bacterial infections to senescence and immunosenescence |
| title_sort | contribution of viral and bacterial infections to senescence and immunosenescence |
| topic | senescence immunosenescence chronic infections persistent infections virus bacteria |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1229098/full |
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