Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota
IntroductionHuman gut dysbiosis has been implicated with the onset of many neurodegenerative disorders. However, the current data focused on the gut microbiota of patients with Creutzfeldt-Jakob disease (CJD) are still lacking. In our study, we explored the gut microbiota alteration in patients with...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.832599/full |
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| author | Yanjun Guo Yichen Xu Xue Lin Zhen Zhen Fang Yi Hongzhi Guan Qi Shi Wenjie Sun Anchao Yang Xiaoping Dong Jiawei Wang |
| author_facet | Yanjun Guo Yichen Xu Xue Lin Zhen Zhen Fang Yi Hongzhi Guan Qi Shi Wenjie Sun Anchao Yang Xiaoping Dong Jiawei Wang |
| author_sort | Yanjun Guo |
| collection | DOAJ |
| description | IntroductionHuman gut dysbiosis has been implicated with the onset of many neurodegenerative disorders. However, the current data focused on the gut microbiota of patients with Creutzfeldt-Jakob disease (CJD) are still lacking. In our study, we explored the gut microbiota alteration in patients with CJD.MethodWe performed 16S ribosomal RNA MiSeq sequencing in stool samples of patients with CJD and controls. Functional analysis of the gut microbiota between these two groups was based on Kyoto Encyclopedia of Genes and Genomes and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2. Clinical rating scales were used to evaluate the association between cognitive impairment and gut microbiota alteration.ResultWe identified a significant alteration in both the structure and the richness of the CJD group. Function analysis revealed that the gut microbiota of patients with CJD enriched in immune signaling molecule interactions and xenobiotics biodegradation. MoCA and survival times were found to be associated with gut microbiota in patients with CJD.ConclusionWe demonstrated an altered gut microbiota in patients with CJD, which was associated with the cognitive impairment and the survival time of these patients. |
| first_indexed | 2024-12-10T13:21:28Z |
| format | Article |
| id | doaj.art-1683a49333104e62a60ebb036b9f5786 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T13:21:28Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-1683a49333104e62a60ebb036b9f57862022-12-22T01:47:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-04-011310.3389/fneur.2022.832599832599Creutzfeldt-Jakob Disease: Alterations of Gut MicrobiotaYanjun Guo0Yichen Xu1Xue Lin2Zhen Zhen3Fang Yi4Hongzhi Guan5Qi Shi6Wenjie Sun7Anchao Yang8Xiaoping Dong9Jiawei Wang10Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Lishilu Outpatient, Central Medical Branch of PLA General Hospital, Beijing, ChinaDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaDepartment of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaIntroductionHuman gut dysbiosis has been implicated with the onset of many neurodegenerative disorders. However, the current data focused on the gut microbiota of patients with Creutzfeldt-Jakob disease (CJD) are still lacking. In our study, we explored the gut microbiota alteration in patients with CJD.MethodWe performed 16S ribosomal RNA MiSeq sequencing in stool samples of patients with CJD and controls. Functional analysis of the gut microbiota between these two groups was based on Kyoto Encyclopedia of Genes and Genomes and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2. Clinical rating scales were used to evaluate the association between cognitive impairment and gut microbiota alteration.ResultWe identified a significant alteration in both the structure and the richness of the CJD group. Function analysis revealed that the gut microbiota of patients with CJD enriched in immune signaling molecule interactions and xenobiotics biodegradation. MoCA and survival times were found to be associated with gut microbiota in patients with CJD.ConclusionWe demonstrated an altered gut microbiota in patients with CJD, which was associated with the cognitive impairment and the survival time of these patients.https://www.frontiersin.org/articles/10.3389/fneur.2022.832599/fullCreutzfeldt-Jakob diseasegut microbiotadysbiosisneurodegenerative diseasegut-brain axis |
| spellingShingle | Yanjun Guo Yichen Xu Xue Lin Zhen Zhen Fang Yi Hongzhi Guan Qi Shi Wenjie Sun Anchao Yang Xiaoping Dong Jiawei Wang Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota Frontiers in Neurology Creutzfeldt-Jakob disease gut microbiota dysbiosis neurodegenerative disease gut-brain axis |
| title | Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota |
| title_full | Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota |
| title_fullStr | Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota |
| title_full_unstemmed | Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota |
| title_short | Creutzfeldt-Jakob Disease: Alterations of Gut Microbiota |
| title_sort | creutzfeldt jakob disease alterations of gut microbiota |
| topic | Creutzfeldt-Jakob disease gut microbiota dysbiosis neurodegenerative disease gut-brain axis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.832599/full |
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