The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y Level
Objective: To compare the Neuropeptide Y (NPY) levels in nonobese Polycystic Ovary Syndrome (PCOS) patients without insulin resistance and non-obese women without insulin resistance, in consideration of the psychopathologic conditions occurring in PCOS patients as well as the influence of these chan...
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| Format: | Article |
| Language: | English |
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Indonesian Society of Obstetrics and Gynecology
2012-07-01
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| Series: | Indonesian Journal of Obstetrics and Gynecology |
| Online Access: | http://inajog.com/index.php/journal/article/view/310 |
| _version_ | 1830193031470383104 |
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| author | Mariza Yustina |
| author_facet | Mariza Yustina |
| author_sort | Mariza Yustina |
| collection | DOAJ |
| description | Objective: To compare the Neuropeptide Y (NPY) levels in nonobese Polycystic Ovary Syndrome (PCOS) patients without insulin resistance and non-obese women without insulin resistance, in consideration of the psychopathologic conditions occurring in PCOS patients as well as the influence of these changes in affecting NPY levels. Methods: The subject was fourteen PCOS patients and 20 non-obese normal women, both without insulin resistance. The measurements of blood NPY levels using the ELISA method and a psychology assessment using Symptom Check List 90 (SCL-90) were carried out. Statistical analysis was performed using SPSS 17. Results: From 20 PCOS patients included in this study, 6 subjects (30%) were detected as having psychopathologic problems through completion of the SCL-90 questionnaire, with a cut-off score of >70 points. Measurement of NPY levels using ELISA found a mean NPY level of 8.02 ± 3.92 (95% CI 2.39 - 18.66) in the PCOS group compared to a mean of 7.78 ± 4.31 pg/ml (95% CI 0.74 - 15.47) in the control group. No significant difference was found in the mean levels of NPY between the two groups. Statistical assessment using the Spearman 2-variable correlation test also found no significant correlation between NPY levels and the SCL-90, scores in the PCOS group. Conclusion: There was no significant difference in NPY levels between the PCOS group and control group. Thirty percent of non-obese PCOS patients without insulin resistance were identified as having psychopathologic conditions. But in this group of patients, the psychopathologic changes had no influence on the levels of blood NPY. [Indones J Obstet Gynecol 2012; 36-3: 125-9] Keywords: neuropeptide Y, PCOS, psychopathologic conditions |
| first_indexed | 2024-12-18T00:05:56Z |
| format | Article |
| id | doaj.art-168459cb3c2048d9afb68ed20d8853bc |
| institution | Directory Open Access Journal |
| issn | 2338-6401 2338-7335 |
| language | English |
| last_indexed | 2024-12-18T00:05:56Z |
| publishDate | 2012-07-01 |
| publisher | Indonesian Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Indonesian Journal of Obstetrics and Gynecology |
| spelling | doaj.art-168459cb3c2048d9afb68ed20d8853bc2022-12-21T21:27:48ZengIndonesian Society of Obstetrics and GynecologyIndonesian Journal of Obstetrics and Gynecology2338-64012338-73352012-07-0112512910.32771/inajog.v36i3.310310The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y LevelMariza Yustina0Department of Obstetrics and Gynecology Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital JakartaObjective: To compare the Neuropeptide Y (NPY) levels in nonobese Polycystic Ovary Syndrome (PCOS) patients without insulin resistance and non-obese women without insulin resistance, in consideration of the psychopathologic conditions occurring in PCOS patients as well as the influence of these changes in affecting NPY levels. Methods: The subject was fourteen PCOS patients and 20 non-obese normal women, both without insulin resistance. The measurements of blood NPY levels using the ELISA method and a psychology assessment using Symptom Check List 90 (SCL-90) were carried out. Statistical analysis was performed using SPSS 17. Results: From 20 PCOS patients included in this study, 6 subjects (30%) were detected as having psychopathologic problems through completion of the SCL-90 questionnaire, with a cut-off score of >70 points. Measurement of NPY levels using ELISA found a mean NPY level of 8.02 ± 3.92 (95% CI 2.39 - 18.66) in the PCOS group compared to a mean of 7.78 ± 4.31 pg/ml (95% CI 0.74 - 15.47) in the control group. No significant difference was found in the mean levels of NPY between the two groups. Statistical assessment using the Spearman 2-variable correlation test also found no significant correlation between NPY levels and the SCL-90, scores in the PCOS group. Conclusion: There was no significant difference in NPY levels between the PCOS group and control group. Thirty percent of non-obese PCOS patients without insulin resistance were identified as having psychopathologic conditions. But in this group of patients, the psychopathologic changes had no influence on the levels of blood NPY. [Indones J Obstet Gynecol 2012; 36-3: 125-9] Keywords: neuropeptide Y, PCOS, psychopathologic conditionshttp://inajog.com/index.php/journal/article/view/310 |
| spellingShingle | Mariza Yustina The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y Level Indonesian Journal of Obstetrics and Gynecology |
| title | The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y Level |
| title_full | The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y Level |
| title_fullStr | The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y Level |
| title_full_unstemmed | The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y Level |
| title_short | The Psychopathology Changes in non-Obese PCOS Women Do Not Show any Influence on Neuropeptide Y Level |
| title_sort | psychopathology changes in non obese pcos women do not show any influence on neuropeptide y level |
| url | http://inajog.com/index.php/journal/article/view/310 |
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