Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients
Background: Oral lichen planus (OLP) is a frequently encountered chronic inflammatory disease of oral mucosa and skin, where the patients often relate the onset and aggravation of oral symptoms to increased levels of stress. Cortisol, also called as “stress hormone” has been used as an indicator...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5225/8058_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(Sh)_PF2(PAG).pdf |
| _version_ | 1818882776109154304 |
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| author | Lakshmi Kavitha Nadendla Venkateswarlu Meduri Geetha Paramkusam Koteswara Rao Pachava |
| author_facet | Lakshmi Kavitha Nadendla Venkateswarlu Meduri Geetha Paramkusam Koteswara Rao Pachava |
| author_sort | Lakshmi Kavitha Nadendla |
| collection | DOAJ |
| description | Background: Oral lichen planus (OLP) is a frequently encountered chronic inflammatory disease of oral mucosa and skin,
where the patients often relate the onset and aggravation of oral
symptoms to increased levels of stress. Cortisol, also called
as “stress hormone” has been used as an indicator in various
stress evaluation studies.
Aim: The aim of this cross-sectional study was to determine
any association between anxiety and salivary cortisol levels in
OLP patients.
Materials and Methods: A total of 20 OLP patients along with
same number of age and sex matched healthy controls were
included in the study. Saliva was collected from all the subjects
between 9.00 to 9.15 am to avoid diurnal variations of cortisol
levels. The saliva samples were analysed for cortisol levels
by competitive enzyme-linked immunosorbent assay (ELISA)
method. Anxiety levels of 40 patients were measured by using
Hamilton’s anxiety scale. Student’s t-test was used to compare
the anxiety and salivary cortisol levels between both groups.
Results: The mean salivary cortisol level of the OLP group
showed highly significant difference (p<0.001) from the controls.
The mean anxiety scores of the OLP group showed highly
significant difference (p<0.001) from the controls. A positive
correlation was found between anxiety and salivary cortisol
levels in the OLP patients.
Conclusion: These findings suggest that anxiety play a vital role
in the pathogenesis of OLP, thus besides traditional treatment,
psychological support is also needed. |
| first_indexed | 2024-12-19T15:23:08Z |
| format | Article |
| id | doaj.art-16891991bec04512aca4268709d98296 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T15:23:08Z |
| publishDate | 2014-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-16891991bec04512aca4268709d982962022-12-21T20:15:57ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-12-01812ZC01ZC0310.7860/JCDR/2014/8058.5225Association of Salivary Cortisol and Anxiety Levels in Lichen Planus PatientsLakshmi Kavitha Nadendla0Venkateswarlu Meduri1Geetha Paramkusam2Koteswara Rao Pachava3Senior Lecturer, Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda, Andhra Pradesh, India.Professor, Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda, Andhra Pradesh, India.Professor and HOD, Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda, Andhra Pradesh, India.Senior Lecturer, Department of Prosthodontics, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda, Andhra Pradesh, India.Background: Oral lichen planus (OLP) is a frequently encountered chronic inflammatory disease of oral mucosa and skin, where the patients often relate the onset and aggravation of oral symptoms to increased levels of stress. Cortisol, also called as “stress hormone” has been used as an indicator in various stress evaluation studies. Aim: The aim of this cross-sectional study was to determine any association between anxiety and salivary cortisol levels in OLP patients. Materials and Methods: A total of 20 OLP patients along with same number of age and sex matched healthy controls were included in the study. Saliva was collected from all the subjects between 9.00 to 9.15 am to avoid diurnal variations of cortisol levels. The saliva samples were analysed for cortisol levels by competitive enzyme-linked immunosorbent assay (ELISA) method. Anxiety levels of 40 patients were measured by using Hamilton’s anxiety scale. Student’s t-test was used to compare the anxiety and salivary cortisol levels between both groups. Results: The mean salivary cortisol level of the OLP group showed highly significant difference (p<0.001) from the controls. The mean anxiety scores of the OLP group showed highly significant difference (p<0.001) from the controls. A positive correlation was found between anxiety and salivary cortisol levels in the OLP patients. Conclusion: These findings suggest that anxiety play a vital role in the pathogenesis of OLP, thus besides traditional treatment, psychological support is also needed.https://jcdr.net/articles/PDF/5225/8058_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(Sh)_PF2(PAG).pdfelisahpa (hypothalamo adrenal)- axisstress |
| spellingShingle | Lakshmi Kavitha Nadendla Venkateswarlu Meduri Geetha Paramkusam Koteswara Rao Pachava Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients Journal of Clinical and Diagnostic Research elisa hpa (hypothalamo adrenal)- axis stress |
| title | Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients |
| title_full | Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients |
| title_fullStr | Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients |
| title_full_unstemmed | Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients |
| title_short | Association of Salivary Cortisol and Anxiety Levels in Lichen Planus Patients |
| title_sort | association of salivary cortisol and anxiety levels in lichen planus patients |
| topic | elisa hpa (hypothalamo adrenal)- axis stress |
| url | https://jcdr.net/articles/PDF/5225/8058_CE(Ra)_F(Sh)_PF1(SNAK)_PFA(Sh)_PF2(PAG).pdf |
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