Lead Optimization of 2-Cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl) methylidene]hydrazinecarbothioamides for Targeting the HER-2 Overexpressed Breast Cancer Cell Line SKBr-3

Lead Optimization of 2-Cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl) methylidene]hydrazinecarbothioamides for Targeting the HER-2 Overexpressed Breast Cancer Cell Line SKBr-3

Lead derivatives of 2-cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl) methylidene]hydrazinecarbothioamides 1–18 were synthesized, characterized and evaluated in vitro against HER-2 overexpressed breast cancer cell line SKBr-3. All the compounds showed activity against HER-2 overexpressed SKBr-3...

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Bibliographic Details
Main Authors: Mashooq A. Bhat, Abdullah Al-Dhfyan, Ahmed M. Naglah, Azmat Ali Khan, Mohamed A. Al-Omar
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Molecules
Subjects:
thiosemicarbazones
HER-2
SKBr-3 cells
BT-474 cells
cancer stem cells
Online Access:http://www.mdpi.com/1420-3049/20/10/18246

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