Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart

Piezo buffers mechanical stress via modulation of intracellular Ca2+ handling in the Drosophila heart

Throughout its lifetime the heart is buffeted continuously by dynamic mechanical forces resulting from contraction of the heart muscle itself and fluctuations in haemodynamic load and pressure. These forces are in flux on a beat-by-beat basis, resulting from changes in posture, physical activity or...

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Bibliographic Details
Main Authors: Luigi Zechini, Julian Camilleri-Brennan, Jonathan Walsh, Robin Beaven, Oscar Moran, Paul S. Hartley, Mary Diaz, Barry Denholm
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Physiology
Subjects:
Piezo
mechanotransduction
Frank-Starling
Drosophila
heart
calcium
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1003999/full

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