NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome
Nerve growth factor (NGF) was the first neurotrophin described. This neurotrophin contributes to organogenesis by promoting sensory innervation and angiogenesis in the endocrine and immune systems. Neuronal and non-neuronal cells produce and secrete NGF, and several cell types throughout the body ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/1957 |
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| author | Jazmín Samario-Román Carlos Larqué Pablo Pánico Rosa Isela Ortiz-Huidobro Myrian Velasco Rene Escalona Marcia Hiriart |
| author_facet | Jazmín Samario-Román Carlos Larqué Pablo Pánico Rosa Isela Ortiz-Huidobro Myrian Velasco Rene Escalona Marcia Hiriart |
| author_sort | Jazmín Samario-Román |
| collection | DOAJ |
| description | Nerve growth factor (NGF) was the first neurotrophin described. This neurotrophin contributes to organogenesis by promoting sensory innervation and angiogenesis in the endocrine and immune systems. Neuronal and non-neuronal cells produce and secrete NGF, and several cell types throughout the body express the high-affinity neurotrophin receptor TrkA and the low-affinity receptor p75NTR. NGF is essential for glucose-stimulated insulin secretion and the complete development of pancreatic islets. Plus, this factor is involved in regulating lipolysis and thermogenesis in adipose tissue. Immune cells produce and respond to NGF, modulating their inflammatory phenotype and the secretion of cytokines, contributing to insulin resistance and metabolic homeostasis. This neurotrophin regulates the synthesis of gonadal steroid hormones, which ultimately participate in the metabolic homeostasis of other tissues. Therefore, we propose that this neurotrophin’s imbalance in concentrations and signaling during metabolic syndrome contribute to its pathophysiology. In the present work, we describe the multiple roles of NGF in immunoendocrine organs that are important in metabolic homeostasis and related to the pathophysiology of metabolic syndrome. |
| first_indexed | 2024-03-11T09:42:32Z |
| format | Article |
| id | doaj.art-168c57002e3344d9bf91d41c61d1d28c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:42:32Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-168c57002e3344d9bf91d41c61d1d28c2023-11-16T16:50:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243195710.3390/ijms24031957NGF and Its Role in Immunoendocrine Communication during Metabolic SyndromeJazmín Samario-Román0Carlos Larqué1Pablo Pánico2Rosa Isela Ortiz-Huidobro3Myrian Velasco4Rene Escalona5Marcia Hiriart6Neuroscience Division, Cognitive Neuroscience Department, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México UNAM, Mexico City 04510, MexicoDepartment of Embryology and Genetics, Facultad de Medicina, Universidad Nacional Autónoma de México UNAM, Mexico City 04510, MexicoNeuroscience Division, Cognitive Neuroscience Department, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México UNAM, Mexico City 04510, MexicoNeuroscience Division, Cognitive Neuroscience Department, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México UNAM, Mexico City 04510, MexicoNeuroscience Division, Cognitive Neuroscience Department, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México UNAM, Mexico City 04510, MexicoDepartment of Embryology and Genetics, Facultad de Medicina, Universidad Nacional Autónoma de México UNAM, Mexico City 04510, MexicoNeuroscience Division, Cognitive Neuroscience Department, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México UNAM, Mexico City 04510, MexicoNerve growth factor (NGF) was the first neurotrophin described. This neurotrophin contributes to organogenesis by promoting sensory innervation and angiogenesis in the endocrine and immune systems. Neuronal and non-neuronal cells produce and secrete NGF, and several cell types throughout the body express the high-affinity neurotrophin receptor TrkA and the low-affinity receptor p75NTR. NGF is essential for glucose-stimulated insulin secretion and the complete development of pancreatic islets. Plus, this factor is involved in regulating lipolysis and thermogenesis in adipose tissue. Immune cells produce and respond to NGF, modulating their inflammatory phenotype and the secretion of cytokines, contributing to insulin resistance and metabolic homeostasis. This neurotrophin regulates the synthesis of gonadal steroid hormones, which ultimately participate in the metabolic homeostasis of other tissues. Therefore, we propose that this neurotrophin’s imbalance in concentrations and signaling during metabolic syndrome contribute to its pathophysiology. In the present work, we describe the multiple roles of NGF in immunoendocrine organs that are important in metabolic homeostasis and related to the pathophysiology of metabolic syndrome.https://www.mdpi.com/1422-0067/24/3/1957metabolismmetabolic homeostasismetabolic diseasesneurotrophinpancreatic beta celladipocytes |
| spellingShingle | Jazmín Samario-Román Carlos Larqué Pablo Pánico Rosa Isela Ortiz-Huidobro Myrian Velasco Rene Escalona Marcia Hiriart NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome International Journal of Molecular Sciences metabolism metabolic homeostasis metabolic diseases neurotrophin pancreatic beta cell adipocytes |
| title | NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome |
| title_full | NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome |
| title_fullStr | NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome |
| title_full_unstemmed | NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome |
| title_short | NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome |
| title_sort | ngf and its role in immunoendocrine communication during metabolic syndrome |
| topic | metabolism metabolic homeostasis metabolic diseases neurotrophin pancreatic beta cell adipocytes |
| url | https://www.mdpi.com/1422-0067/24/3/1957 |
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