Identification of Multipotent Progenitors that Emerge Prior to Hematopoietic Stem Cells in Embryonic Development

Hematopoiesis in the embryo proceeds in a series of waves, with primitive erythroid-biased waves succeeded by definitive waves, within which the properties of hematopoietic stem cells (multilineage potential, self-renewal, and engraftability) gradually arise. Whereas self-renewal and engraftability...

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Bibliographic Details
Main Authors: Matthew A. Inlay, Thomas Serwold, Adriane Mosley, John W. Fathman, Ivan K. Dimov, Jun Seita, Irving L. Weissman
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114000526