A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China

BackgroundAlthough Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by park...

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Bibliographic Details
Main Authors: Hong-xing Li, Mei Dong, Xiao-xiao Peng, Yi-zhe Liu, Han Wang, Chao Li, Yi-yi Du, Kai Zhang, Qiang Zong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neurology
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Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1103164/full
Description
Summary:BackgroundAlthough Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by parkin RBR E3 ubiquitin protein ligase (PRKN) mutations.CaseIn this study, we report the case of a 30-year-old Chinese woman who was affected by PRKN-associated YOPD and was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through an uncomplicated vaginal delivery.ConclusionThis case further suggests that levodopa/benserazide during pregnancy is safe in the treatment of PRKN-associated YOPD.
ISSN:1664-2295