A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China
BackgroundAlthough Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by park...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1103164/full |
| _version_ | 1797902936123113472 |
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| author | Hong-xing Li Mei Dong Xiao-xiao Peng Yi-zhe Liu Han Wang Chao Li Yi-yi Du Kai Zhang Qiang Zong |
| author_facet | Hong-xing Li Mei Dong Xiao-xiao Peng Yi-zhe Liu Han Wang Chao Li Yi-yi Du Kai Zhang Qiang Zong |
| author_sort | Hong-xing Li |
| collection | DOAJ |
| description | BackgroundAlthough Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by parkin RBR E3 ubiquitin protein ligase (PRKN) mutations.CaseIn this study, we report the case of a 30-year-old Chinese woman who was affected by PRKN-associated YOPD and was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through an uncomplicated vaginal delivery.ConclusionThis case further suggests that levodopa/benserazide during pregnancy is safe in the treatment of PRKN-associated YOPD. |
| first_indexed | 2024-04-10T09:25:05Z |
| format | Article |
| id | doaj.art-168d0466109d4cf2a7f79c74c5fea6ff |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T09:25:05Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-168d0466109d4cf2a7f79c74c5fea6ff2023-02-20T04:35:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.11031641103164A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in ChinaHong-xing Li0Mei Dong1Xiao-xiao Peng2Yi-zhe Liu3Han Wang4Chao Li5Yi-yi Du6Kai Zhang7Qiang Zong8Department of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, ChinaDepartment of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, ChinaDepartment of Stomatology, Dongying District People's Hospital, Dongying, Shandong, ChinaDepartment of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, ChinaDepartment of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, ChinaDepartment of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, ChinaDepartment of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, ChinaDepartment of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, ChinaDepartment of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, ChinaBackgroundAlthough Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by parkin RBR E3 ubiquitin protein ligase (PRKN) mutations.CaseIn this study, we report the case of a 30-year-old Chinese woman who was affected by PRKN-associated YOPD and was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through an uncomplicated vaginal delivery.ConclusionThis case further suggests that levodopa/benserazide during pregnancy is safe in the treatment of PRKN-associated YOPD.https://www.frontiersin.org/articles/10.3389/fneur.2023.1103164/fullParkinson's diseaseyoung-onset PDpregnancyPRKN genelevodopa/benserazide |
| spellingShingle | Hong-xing Li Mei Dong Xiao-xiao Peng Yi-zhe Liu Han Wang Chao Li Yi-yi Du Kai Zhang Qiang Zong A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China Frontiers in Neurology Parkinson's disease young-onset PD pregnancy PRKN gene levodopa/benserazide |
| title | A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China |
| title_full | A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China |
| title_fullStr | A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China |
| title_full_unstemmed | A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China |
| title_short | A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China |
| title_sort | homozygous prkn associated juvenile parkinson s disease with pregnancy in china |
| topic | Parkinson's disease young-onset PD pregnancy PRKN gene levodopa/benserazide |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1103164/full |
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