Serum amyloid P and endocrine markers in a cohort of obese children
Objectives: Obesity in children can lead to morbidity and mortality due to metabolic and inflammatory comorbidities. Aims: The objective of the study was to investigate the alterations in acute inflammatory markers, serum amyloid P (SAP) and cortisol, and endocrine markers, leptin and insulin, in ob...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2018;volume=22;issue=5;spage=683;epage=688;aulast=Anwer |
| _version_ | 1818390714992558080 |
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| author | Mehwish Anwer Muhammad J Iqbal |
| author_facet | Mehwish Anwer Muhammad J Iqbal |
| author_sort | Mehwish Anwer |
| collection | DOAJ |
| description | Objectives: Obesity in children can lead to morbidity and mortality due to metabolic and inflammatory comorbidities. Aims: The objective of the study was to investigate the alterations in acute inflammatory markers, serum amyloid P (SAP) and cortisol, and endocrine markers, leptin and insulin, in obese children. Materials and Methods: Serum leptin, insulin, cortisol, and amyloid P concentrations were measured in obese (BMI percentile >85, n = 17) and nonobese (BMI percentile < 75, n = 20) children using ELISA and Bio-Plex Bead-based assay. Statistical Analysis Used: Serum concentrations of analytes were compared between normal and obese groups using 2-tailed student's t-test. Results: Mean leptin, insulin, and SAP serum concentrations were significantly higher in obese children as compared to the controls (97.19 vs. 4.06, P < 0.05; 21.31 vs 3.56, P < 0.05; 46.77 vs. 17.89, P < 0.05; respectively). No difference was found in mean serum cortisol levels of the two groups. However, cortisol values were higher in obese subjects compared to the control group (7.89 vs 6.30, P = 0.15). Leptin corelated with insulin (r = 0.42, P = 0.043) and cortisol (r = 0.48, P = 0.025) levels in the obese group. Furthermore, leptin, insulin, and SAP levels were corelated with BMI (r = 0.80, P < 0.000; r = 0.67, P = 0.015, respectively) and body weight (r = 0.52, P = 0.01; r = 0.52, P = 0.002; r = 0.54, P = 0.01, respectively) in the obese group but did not demonstrate a significant relationship in the nonobese group. Conclusion: Elevated SAP levels and increase in leptin and insulin indicated a preeminent disposition of morbidly obese children to the development of low-grade inflammation and metabolic syndrome. |
| first_indexed | 2024-12-14T05:02:02Z |
| format | Article |
| id | doaj.art-168f6d0a9b1c49a4a905f363cceb8c99 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-12-14T05:02:02Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-168f6d0a9b1c49a4a905f363cceb8c992022-12-21T23:16:13ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102018-01-0122568368810.4103/ijem.IJEM_66_18Serum amyloid P and endocrine markers in a cohort of obese childrenMehwish AnwerMuhammad J IqbalObjectives: Obesity in children can lead to morbidity and mortality due to metabolic and inflammatory comorbidities. Aims: The objective of the study was to investigate the alterations in acute inflammatory markers, serum amyloid P (SAP) and cortisol, and endocrine markers, leptin and insulin, in obese children. Materials and Methods: Serum leptin, insulin, cortisol, and amyloid P concentrations were measured in obese (BMI percentile >85, n = 17) and nonobese (BMI percentile < 75, n = 20) children using ELISA and Bio-Plex Bead-based assay. Statistical Analysis Used: Serum concentrations of analytes were compared between normal and obese groups using 2-tailed student's t-test. Results: Mean leptin, insulin, and SAP serum concentrations were significantly higher in obese children as compared to the controls (97.19 vs. 4.06, P < 0.05; 21.31 vs 3.56, P < 0.05; 46.77 vs. 17.89, P < 0.05; respectively). No difference was found in mean serum cortisol levels of the two groups. However, cortisol values were higher in obese subjects compared to the control group (7.89 vs 6.30, P = 0.15). Leptin corelated with insulin (r = 0.42, P = 0.043) and cortisol (r = 0.48, P = 0.025) levels in the obese group. Furthermore, leptin, insulin, and SAP levels were corelated with BMI (r = 0.80, P < 0.000; r = 0.67, P = 0.015, respectively) and body weight (r = 0.52, P = 0.01; r = 0.52, P = 0.002; r = 0.54, P = 0.01, respectively) in the obese group but did not demonstrate a significant relationship in the nonobese group. Conclusion: Elevated SAP levels and increase in leptin and insulin indicated a preeminent disposition of morbidly obese children to the development of low-grade inflammation and metabolic syndrome.http://www.ijem.in/article.asp?issn=2230-8210;year=2018;volume=22;issue=5;spage=683;epage=688;aulast=AnwerCortisolinflammationinsulinleptinmetabolic syndromeserum amyloid P |
| spellingShingle | Mehwish Anwer Muhammad J Iqbal Serum amyloid P and endocrine markers in a cohort of obese children Indian Journal of Endocrinology and Metabolism Cortisol inflammation insulin leptin metabolic syndrome serum amyloid P |
| title | Serum amyloid P and endocrine markers in a cohort of obese children |
| title_full | Serum amyloid P and endocrine markers in a cohort of obese children |
| title_fullStr | Serum amyloid P and endocrine markers in a cohort of obese children |
| title_full_unstemmed | Serum amyloid P and endocrine markers in a cohort of obese children |
| title_short | Serum amyloid P and endocrine markers in a cohort of obese children |
| title_sort | serum amyloid p and endocrine markers in a cohort of obese children |
| topic | Cortisol inflammation insulin leptin metabolic syndrome serum amyloid P |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2018;volume=22;issue=5;spage=683;epage=688;aulast=Anwer |
| work_keys_str_mv | AT mehwishanwer serumamyloidpandendocrinemarkersinacohortofobesechildren AT muhammadjiqbal serumamyloidpandendocrinemarkersinacohortofobesechildren |