Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features
BackgroundChronic obstructive pulmonary disease (COPD), a preventable lung disease, has the highest prevalence in the elderly and deserves special consideration regarding earlier warnings in this fragile population. The impact of age on COPD is well known, but the COPD risk of the aging process in t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.845286/full |
| _version_ | 1818255244943949824 |
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| author | Yingjian Yang Yingjian Yang Wei Li Yingwei Guo Yingwei Guo Yang Liu Qiang Li Qiang Li Kai Yang Shicong Wang Nanrong Zeng Wenxin Duan Ziran Chen Huai Chen Xian Li Wei Zhao Rongchang Chen Rongchang Chen Rongchang Chen Yan Kang Yan Kang Yan Kang |
| author_facet | Yingjian Yang Yingjian Yang Wei Li Yingwei Guo Yingwei Guo Yang Liu Qiang Li Qiang Li Kai Yang Shicong Wang Nanrong Zeng Wenxin Duan Ziran Chen Huai Chen Xian Li Wei Zhao Rongchang Chen Rongchang Chen Rongchang Chen Yan Kang Yan Kang Yan Kang |
| author_sort | Yingjian Yang |
| collection | DOAJ |
| description | BackgroundChronic obstructive pulmonary disease (COPD), a preventable lung disease, has the highest prevalence in the elderly and deserves special consideration regarding earlier warnings in this fragile population. The impact of age on COPD is well known, but the COPD risk of the aging process in the lungs remains unclear. Therefore, it is necessary to understand the COPD risk of the aging process in the lungs, providing an early COPD risk decision for adults.MethodsCOPD risk is evaluated for adults to make an early COPD risk decision from the perspective of lung radiomics features. First, the subjects are divided into four groups according to the COPD stages. Their ages are divided into eight equal age intervals in each group. Second, four survival Cox models are established based on the lung radiomics features to evaluate the risk probability from COPD stage 0 to suffering COPD and COPD stages. Finally, four risk ranks are defined by equally dividing the COPD risk probability from 0 to 1. Subsequently, the COPD risk at different stages is evaluated with varying age intervals to provide an early COPD risk decision.ResultsThe evaluation metrics area under the curve (AUC)/C index of four survival Cox models are 0.87/0.94, 0.84/0.83, 0.94/0.89, and 0.97/0.86, respectively, showing the effectiveness of the models. The risk rank levels up every 5 years for the subjects who had suffered COPD after 60. For the subjects with COPD stage 0, the risk rank of suffering COPD stage I levels up every 5 years after the age of 65 years, and the risk rank of suffering COPD stages II and III & IV levels up every 5 years after the age of 70 years.ConclusionOnce the age is above 60 years, the patients with COPD need to take action to prevent the progress and deterioration of COPD. Once the age is above 65 years, the patients with COPD stage 0 need to take precautions against COPD. |
| first_indexed | 2024-12-12T17:08:47Z |
| format | Article |
| id | doaj.art-16907200ca4a4d6bbd15f483e6a0d673 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T17:08:47Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-16907200ca4a4d6bbd15f483e6a0d6732022-12-22T00:17:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.845286845286Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics FeaturesYingjian Yang0Yingjian Yang1Wei Li2Yingwei Guo3Yingwei Guo4Yang Liu5Qiang Li6Qiang Li7Kai Yang8Shicong Wang9Nanrong Zeng10Wenxin Duan11Ziran Chen12Huai Chen13Xian Li14Wei Zhao15Rongchang Chen16Rongchang Chen17Rongchang Chen18Yan Kang19Yan Kang20Yan Kang21College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaShenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital, Shenzhen, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaDepartment of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaMedical Engineering, Liaoning Provincial Crops Hospital of Chinese People's Armed Police Forces, Shenyang, ChinaShenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital, Shenzhen, ChinaThe Second Clinical Medical College, Jinan University, Guangzhou, ChinaThe First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, ChinaCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, ChinaMedical Device Innovation Center, Shenzhen Technology University, Shenzhen, ChinaEngineering Research Centre of Medical Imaging and Intelligent Analysis, Ministry of Education, Shenyang, ChinaBackgroundChronic obstructive pulmonary disease (COPD), a preventable lung disease, has the highest prevalence in the elderly and deserves special consideration regarding earlier warnings in this fragile population. The impact of age on COPD is well known, but the COPD risk of the aging process in the lungs remains unclear. Therefore, it is necessary to understand the COPD risk of the aging process in the lungs, providing an early COPD risk decision for adults.MethodsCOPD risk is evaluated for adults to make an early COPD risk decision from the perspective of lung radiomics features. First, the subjects are divided into four groups according to the COPD stages. Their ages are divided into eight equal age intervals in each group. Second, four survival Cox models are established based on the lung radiomics features to evaluate the risk probability from COPD stage 0 to suffering COPD and COPD stages. Finally, four risk ranks are defined by equally dividing the COPD risk probability from 0 to 1. Subsequently, the COPD risk at different stages is evaluated with varying age intervals to provide an early COPD risk decision.ResultsThe evaluation metrics area under the curve (AUC)/C index of four survival Cox models are 0.87/0.94, 0.84/0.83, 0.94/0.89, and 0.97/0.86, respectively, showing the effectiveness of the models. The risk rank levels up every 5 years for the subjects who had suffered COPD after 60. For the subjects with COPD stage 0, the risk rank of suffering COPD stage I levels up every 5 years after the age of 65 years, and the risk rank of suffering COPD stages II and III & IV levels up every 5 years after the age of 70 years.ConclusionOnce the age is above 60 years, the patients with COPD need to take action to prevent the progress and deterioration of COPD. Once the age is above 65 years, the patients with COPD stage 0 need to take precautions against COPD.https://www.frontiersin.org/articles/10.3389/fmed.2022.845286/fullCOPD riskagingCOPD stage (GOLD)radiomicsearly decisionsurvival Cox model |
| spellingShingle | Yingjian Yang Yingjian Yang Wei Li Yingwei Guo Yingwei Guo Yang Liu Qiang Li Qiang Li Kai Yang Shicong Wang Nanrong Zeng Wenxin Duan Ziran Chen Huai Chen Xian Li Wei Zhao Rongchang Chen Rongchang Chen Rongchang Chen Yan Kang Yan Kang Yan Kang Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features Frontiers in Medicine COPD risk aging COPD stage (GOLD) radiomics early decision survival Cox model |
| title | Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features |
| title_full | Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features |
| title_fullStr | Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features |
| title_full_unstemmed | Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features |
| title_short | Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features |
| title_sort | early copd risk decision for adults aged from 40 to 79 years based on lung radiomics features |
| topic | COPD risk aging COPD stage (GOLD) radiomics early decision survival Cox model |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.845286/full |
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