Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control
Klotho concentration may be considered as a prognostic factor in the development of chronic complications of diabetes. Moreover, decrease in sKlotho concentration may contribute to beta cell apoptosis and type 1 diabetes development. The aim of this study was to evaluate if sKlotho protein concentra...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.709564/full |
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| author | Agnieszka Zubkiewicz-Kucharska Beata Wikiera Anna Noczyńska |
| author_facet | Agnieszka Zubkiewicz-Kucharska Beata Wikiera Anna Noczyńska |
| author_sort | Agnieszka Zubkiewicz-Kucharska |
| collection | DOAJ |
| description | Klotho concentration may be considered as a prognostic factor in the development of chronic complications of diabetes. Moreover, decrease in sKlotho concentration may contribute to beta cell apoptosis and type 1 diabetes development. The aim of this study was to evaluate if sKlotho protein concentration in children with type 1 diabetes (T1D) and its correlation with classical risk factors of chronic complications of diabetes: dysglycemia and endothelial dysfunction.Material and methodsIn a cross-section single center study the levels of soluble Klotho protein in 80 T1D (37 boys) and 34 healthy children (controls, 15 boys). Micro- and macroangiopathy were excluded and renal function was normal in all participants. Serum sKlotho, sICAM-1, sVCAM-1 and E-selectin levels were measured.ResultsThe concentration of sKlotho was lower in T1D than in the controls (2041.9 ± 1017.6 pg/mL vs. 2790.3 ± 1423.9 pg/mL, p=0.0113). sICAM-1, sVCAM-1 and E-selectin concentrations were comparable in patients and controls. In T1D, sKlotho was not correlated with the duration of diabetes. Klotho and E-selectin were correlated with HbA1c (r=-0.31, P=0.0066 and r=0.25, P=0.0351, respectively), but not with AVBG and blood glucose SD. Correlations of sKlotho with total cholesterol (r=0.31, P=0.0129), HDL-cholesterol (r=0.43, P=0.0011) and LDL-cholesterol (r=0.28, P=0.0412), but not with triglycerides, were found. Likewise, Klotho was not correlated with sICAM-1, sVCAM-1, and E-selectin concentrations.ConclusionsThis study reports the significantly lower level of s-Klotho in children with type 1 diabetes, correlated with HbA1c and HDL cholesterol, but not with the adhesion molecules concentrations nor the duration of the disease. Negative correlation between the levels of HbA1c and soluble Klotho may suggest its possible involvement in the development of chronic diabetes complications. |
| first_indexed | 2024-12-22T10:19:52Z |
| format | Article |
| id | doaj.art-169080b100dc496c97bc521752d39119 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-22T10:19:52Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-169080b100dc496c97bc521752d391192022-12-21T18:29:39ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-09-011210.3389/fendo.2021.709564709564Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic ControlAgnieszka Zubkiewicz-KucharskaBeata WikieraAnna NoczyńskaKlotho concentration may be considered as a prognostic factor in the development of chronic complications of diabetes. Moreover, decrease in sKlotho concentration may contribute to beta cell apoptosis and type 1 diabetes development. The aim of this study was to evaluate if sKlotho protein concentration in children with type 1 diabetes (T1D) and its correlation with classical risk factors of chronic complications of diabetes: dysglycemia and endothelial dysfunction.Material and methodsIn a cross-section single center study the levels of soluble Klotho protein in 80 T1D (37 boys) and 34 healthy children (controls, 15 boys). Micro- and macroangiopathy were excluded and renal function was normal in all participants. Serum sKlotho, sICAM-1, sVCAM-1 and E-selectin levels were measured.ResultsThe concentration of sKlotho was lower in T1D than in the controls (2041.9 ± 1017.6 pg/mL vs. 2790.3 ± 1423.9 pg/mL, p=0.0113). sICAM-1, sVCAM-1 and E-selectin concentrations were comparable in patients and controls. In T1D, sKlotho was not correlated with the duration of diabetes. Klotho and E-selectin were correlated with HbA1c (r=-0.31, P=0.0066 and r=0.25, P=0.0351, respectively), but not with AVBG and blood glucose SD. Correlations of sKlotho with total cholesterol (r=0.31, P=0.0129), HDL-cholesterol (r=0.43, P=0.0011) and LDL-cholesterol (r=0.28, P=0.0412), but not with triglycerides, were found. Likewise, Klotho was not correlated with sICAM-1, sVCAM-1, and E-selectin concentrations.ConclusionsThis study reports the significantly lower level of s-Klotho in children with type 1 diabetes, correlated with HbA1c and HDL cholesterol, but not with the adhesion molecules concentrations nor the duration of the disease. Negative correlation between the levels of HbA1c and soluble Klotho may suggest its possible involvement in the development of chronic diabetes complications.https://www.frontiersin.org/articles/10.3389/fendo.2021.709564/fullKlothotype 1 diabeteschildrenmetabolic controlcomplications of diabetes |
| spellingShingle | Agnieszka Zubkiewicz-Kucharska Beata Wikiera Anna Noczyńska Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control Frontiers in Endocrinology Klotho type 1 diabetes children metabolic control complications of diabetes |
| title | Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control |
| title_full | Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control |
| title_fullStr | Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control |
| title_full_unstemmed | Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control |
| title_short | Soluble Klotho Is Decreased in Children With Type 1 Diabetes and Correlated With Metabolic Control |
| title_sort | soluble klotho is decreased in children with type 1 diabetes and correlated with metabolic control |
| topic | Klotho type 1 diabetes children metabolic control complications of diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.709564/full |
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