The basic chemistry of exercise-induced DNA oxidation: oxidative damage, redox signalling and their interplay

The basic chemistry of exercise-induced DNA oxidation: oxidative damage, redox signalling and their interplay

Acute exercise increases reactive oxygen and nitrogen species generation. This phenomenon is associated with two major outcomes: (1) redox signalling and (2) macromolecule damage. Mechanistic knowledge of how exercise-induced redox signalling and macromolecule damage are interlinked is limited. This...

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Bibliographic Details
Main Authors: James Nathan Cobley, Nikos V Margaritelis, James P Morton, Graeme Leonard Close, Michalis G. Nikolaidis, John K Malone
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Physiology
Subjects:
DNA Damage
Exercise
Hydrogen Peroxide
Hydroxyl Radical
Redox signalling
mitochondrial DNA damage
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00182/full

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