Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms
Abstract Myeloproliferative neoplasms (MPNs) encompass a diverse group of hematologic disorders driven by mutations in JAK2, CALR, or MPL. The prevailing working model explaining how these driver mutations induce different disease phenotypes is based on the decisive influence of the cellular microen...
Main Authors: | Kristin Holl, Nicolas Chatain, Susanne Krapp, Julian Baumeister, Tiago Maié, Sarah Schmitz, Anja Scheufen, Nathalie Brock, Steffen Koschmieder, Daniel Moreno-Andrés |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-02-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-024-53240-8 |
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