#362: Importance of Monitoring Progesterone(P4) Values a Day Before D5 FET and Effect of Intervention with Progesterone Supplements in Cases with Low P4 Values
Background and Aims: Our study was carried out at a tertiary fertility Centre- Hyderabad, to study the importance of monitoring P4 values, day before D5FET and intervention with progesterone supplements in case of low levels and its outcome. Methods: This is a retrospective cohort study done by anal...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2023-12-01
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| Series: | Fertility & Reproduction |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661318223741371 |
| _version_ | 1797236976036872192 |
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| author | Lakshmi Chirumamilla Divya Reddy Ambavarapu Pranitha Reshmi Volesingamreddy |
| author_facet | Lakshmi Chirumamilla Divya Reddy Ambavarapu Pranitha Reshmi Volesingamreddy |
| author_sort | Lakshmi Chirumamilla |
| collection | DOAJ |
| description | Background and Aims: Our study was carried out at a tertiary fertility Centre- Hyderabad, to study the importance of monitoring P4 values, day before D5FET and intervention with progesterone supplements in case of low levels and its outcome. Methods: This is a retrospective cohort study done by analyzing all D5FET cases and cases with low P4 values were given progesterone supplements and its effect on outcome were studied. Done between 1/01/22-31/03/23, a period of 15 months. Excluded donor, D3nD6 cycles. Results: In a 15 months period, there were 466 D5FET cycles which were included in our study. The age group of women were between 21-45 years and their P4 values, day before D5FET were studied. Around 290(62.2%) cases had levels between 11-20 ng/ml. Among them, 217 conceived being 74.8%. There were 79(16.9%) people who had levels between 21-30 ng/ml among whom 60 conceived with success rate being 75.9%. There were 97 cases who had levels less than 10 ng/ml. If their levels were less than 8ng/ml, they received aqueous progesterone 25 mg subcutaneously twice, 12 hours apart. If levels were between 8-10 ng/ml, they received micronized progesterone 200 mg per rectum twice, 12 hrs apart. The positive pregnancy rate came up to 76.2% among people who received supplementation. In fact, there were 4 people who had levels <5 ng/ml, all four received aqueous progesterone and conceived. Conclusion: Our study concludes that evaluating P4 values day before D5FET is of vital importance. Timely supplementation helps in positive pregnancy rate at par with people with optimum levels of P4. |
| first_indexed | 2024-04-24T17:12:24Z |
| format | Article |
| id | doaj.art-1692e745790b414186a32528c4214dd2 |
| institution | Directory Open Access Journal |
| issn | 2661-3182 2661-3174 |
| language | English |
| last_indexed | 2024-04-24T17:12:24Z |
| publishDate | 2023-12-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Fertility & Reproduction |
| spelling | doaj.art-1692e745790b414186a32528c4214dd22024-03-28T07:54:19ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742023-12-01050432632610.1142/S2661318223741371#362: Importance of Monitoring Progesterone(P4) Values a Day Before D5 FET and Effect of Intervention with Progesterone Supplements in Cases with Low P4 ValuesLakshmi Chirumamilla0Divya Reddy Ambavarapu1Pranitha Reshmi Volesingamreddy2Nova Ivf Fertility Centre, Hyderabad, IndiaNova Ivf Fertility Centre, Hyderabad, IndiaNova Ivf Fertility Centre, Hyderabad, IndiaBackground and Aims: Our study was carried out at a tertiary fertility Centre- Hyderabad, to study the importance of monitoring P4 values, day before D5FET and intervention with progesterone supplements in case of low levels and its outcome. Methods: This is a retrospective cohort study done by analyzing all D5FET cases and cases with low P4 values were given progesterone supplements and its effect on outcome were studied. Done between 1/01/22-31/03/23, a period of 15 months. Excluded donor, D3nD6 cycles. Results: In a 15 months period, there were 466 D5FET cycles which were included in our study. The age group of women were between 21-45 years and their P4 values, day before D5FET were studied. Around 290(62.2%) cases had levels between 11-20 ng/ml. Among them, 217 conceived being 74.8%. There were 79(16.9%) people who had levels between 21-30 ng/ml among whom 60 conceived with success rate being 75.9%. There were 97 cases who had levels less than 10 ng/ml. If their levels were less than 8ng/ml, they received aqueous progesterone 25 mg subcutaneously twice, 12 hours apart. If levels were between 8-10 ng/ml, they received micronized progesterone 200 mg per rectum twice, 12 hrs apart. The positive pregnancy rate came up to 76.2% among people who received supplementation. In fact, there were 4 people who had levels <5 ng/ml, all four received aqueous progesterone and conceived. Conclusion: Our study concludes that evaluating P4 values day before D5FET is of vital importance. Timely supplementation helps in positive pregnancy rate at par with people with optimum levels of P4.https://www.worldscientific.com/doi/10.1142/S2661318223741371 |
| spellingShingle | Lakshmi Chirumamilla Divya Reddy Ambavarapu Pranitha Reshmi Volesingamreddy #362: Importance of Monitoring Progesterone(P4) Values a Day Before D5 FET and Effect of Intervention with Progesterone Supplements in Cases with Low P4 Values Fertility & Reproduction |
| title | #362: Importance of Monitoring Progesterone(P4) Values a Day Before D5 FET and Effect of Intervention with Progesterone Supplements in Cases with Low P4 Values |
| title_full | #362: Importance of Monitoring Progesterone(P4) Values a Day Before D5 FET and Effect of Intervention with Progesterone Supplements in Cases with Low P4 Values |
| title_fullStr | #362: Importance of Monitoring Progesterone(P4) Values a Day Before D5 FET and Effect of Intervention with Progesterone Supplements in Cases with Low P4 Values |
| title_full_unstemmed | #362: Importance of Monitoring Progesterone(P4) Values a Day Before D5 FET and Effect of Intervention with Progesterone Supplements in Cases with Low P4 Values |
| title_short | #362: Importance of Monitoring Progesterone(P4) Values a Day Before D5 FET and Effect of Intervention with Progesterone Supplements in Cases with Low P4 Values |
| title_sort | 362 importance of monitoring progesterone p4 values a day before d5 fet and effect of intervention with progesterone supplements in cases with low p4 values |
| url | https://www.worldscientific.com/doi/10.1142/S2661318223741371 |
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