Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival
Uveal melanoma is the most common primary intraocular malignancy in adults. The development of distant metastases is associated with a poor prognosis. Ephrine receptors (Eph) are the largest subpopulation of tyrosine kinase receptors. They play an important role in processes related to the formation...
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MDPI AG
2020-09-01
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| Online Access: | https://www.mdpi.com/2075-1729/10/10/225 |
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| author | Malgorzata Gajdzis Stamatios Theocharis Pawel Gajdzis Nathalie Cassoux Sophie Gardrat Piotr Donizy Jerzy Klijanienko Radoslaw Kaczmarek |
| author_facet | Malgorzata Gajdzis Stamatios Theocharis Pawel Gajdzis Nathalie Cassoux Sophie Gardrat Piotr Donizy Jerzy Klijanienko Radoslaw Kaczmarek |
| author_sort | Malgorzata Gajdzis |
| collection | DOAJ |
| description | Uveal melanoma is the most common primary intraocular malignancy in adults. The development of distant metastases is associated with a poor prognosis. Ephrine receptors (Eph) are the largest subpopulation of tyrosine kinase receptors. They play an important role in processes related to the formation and progression of cancer. The aim of the study was to evaluate the expression of ephrin receptors EphA1, EphA5, and EphA7 in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. The study included 94 previously untreated patients who underwent enucleation due to uveal melanoma. High expression of EphA1 was positively correlated with a smaller tumor size, less frequent extra-scleral extension, lower mitotic activity, and more frequent vitreous hemorrhage. High expression of EphA5 was associated with less frequent chromosome 3 loss, absence of distant metastases, and more frequent vitreous hemorrhage. High expression of EphA7 was associated with a more frequent primary tumor location in the posterior pole. High EphA5 expression was associated with longer overall survival time. The above findings indicate that high expression of EphA1 and EphA5 can be considered a beneficial prognostic factor in uveal melanoma. |
| first_indexed | 2024-03-10T15:55:34Z |
| format | Article |
| id | doaj.art-169359a4530f4249b2a294f040675507 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T15:55:34Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-169359a4530f4249b2a294f0406755072023-11-20T15:38:18ZengMDPI AGLife2075-17292020-09-01101022510.3390/life10100225Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient SurvivalMalgorzata Gajdzis0Stamatios Theocharis1Pawel Gajdzis2Nathalie Cassoux3Sophie Gardrat4Piotr Donizy5Jerzy Klijanienko6Radoslaw Kaczmarek7Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, PolandFirst Department of Pathology, National and Kapodistrian University of Athens, 15772 Athens, GreeceDepartment of Pathology, Curie Institute, 75005 Paris, FranceDepartment of Ophthalmology, Institut Curie, 75005 Paris, FranceDepartment of Biopathology, Institut Curie, PSL Research University, 75005 Paris, FranceDepartment of Pathomorphology and Oncological Cytology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Pathology, Curie Institute, 75005 Paris, FranceDepartment of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, PolandUveal melanoma is the most common primary intraocular malignancy in adults. The development of distant metastases is associated with a poor prognosis. Ephrine receptors (Eph) are the largest subpopulation of tyrosine kinase receptors. They play an important role in processes related to the formation and progression of cancer. The aim of the study was to evaluate the expression of ephrin receptors EphA1, EphA5, and EphA7 in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. The study included 94 previously untreated patients who underwent enucleation due to uveal melanoma. High expression of EphA1 was positively correlated with a smaller tumor size, less frequent extra-scleral extension, lower mitotic activity, and more frequent vitreous hemorrhage. High expression of EphA5 was associated with less frequent chromosome 3 loss, absence of distant metastases, and more frequent vitreous hemorrhage. High expression of EphA7 was associated with a more frequent primary tumor location in the posterior pole. High EphA5 expression was associated with longer overall survival time. The above findings indicate that high expression of EphA1 and EphA5 can be considered a beneficial prognostic factor in uveal melanoma.https://www.mdpi.com/2075-1729/10/10/225ephrin receptorEphuveal melanomamelanoma |
| spellingShingle | Malgorzata Gajdzis Stamatios Theocharis Pawel Gajdzis Nathalie Cassoux Sophie Gardrat Piotr Donizy Jerzy Klijanienko Radoslaw Kaczmarek Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival Life ephrin receptor Eph uveal melanoma melanoma |
| title | Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival |
| title_full | Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival |
| title_fullStr | Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival |
| title_full_unstemmed | Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival |
| title_short | Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival |
| title_sort | ephrin receptors eph epha1 epha5 and epha7 expression in uveal melanoma associations with clinical parameters and patient survival |
| topic | ephrin receptor Eph uveal melanoma melanoma |
| url | https://www.mdpi.com/2075-1729/10/10/225 |
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