Ten-year follow-up of corneal cross-linking and refractive surface ablation in patients with asymmetric corneal topography

Ten-year follow-up of corneal cross-linking and refractive surface ablation in patients with asymmetric corneal topography

Purpose: Compare the safety and efficacy of wavefront-guided photorefractive keratotomy (PRK) 6 months after cross-linking (CXL) to wavefront-guided PRK alone for refractive correction in patients with bilateral asymmetric corneal topography. Methods: Prospective randomized clinical trial with 16 pa...

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Bibliographic Details
Main Authors: Bernardo Kaplan Moscovici, Pablo Felipe Rodrigues, Marcos Paulo Suehiro Dantas, Juliana Taemy Okimoto, Obidulho Sakassegawa Naves, Felipe Marques de Carvalho Taguchi, João Baptista Nigro Santiago Malta, Mauro Campos
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Indian Journal of Ophthalmology
Subjects:
cornea
corneal stroma
corneal topography
excimer
lasers
photorefractive keratectomy
refractive surgery
Online Access:http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=9;spage=3210;epage=3218;aulast=Moscovici
Description
Summary:Purpose: Compare the safety and efficacy of wavefront-guided photorefractive keratotomy (PRK) 6 months after cross-linking (CXL) to wavefront-guided PRK alone for refractive correction in patients with bilateral asymmetric corneal topography. Methods: Prospective randomized clinical trial with 16 patients (32 eyes). CXL with subsequent PRK after 6 months in one eye, and PRK alone was performed in contralateral eyes. The follow-up was 10 years. We analyzed visual outcomes, Scheimpflug topography, and corneal haze evaluation. Results: Eyes in the PRK group showed better results than in the CXL + PRK group. Mean postoperative CDVA was 0.044 logmar (SD, 0.073) in the PRK group and 0.1 logmar (SD, 0.21) in the CXL + PRK group, the mean sphere was + 0.21 (SD, 0.6) D in the PRK group and 0.87 (SD, 2.3) D in the CXL + PRK group, and mean SE was −0.35 (SD, 0.65) D in the PRK group and 0.62 (SD, 2.32) D in the CXL + PRK group. In one patient, a steepening of 2.5 D and a thinning of 17 μm occurred in PRK alone group. Two patients in the CXL + PRK group presented corneal haze. The overall complication rate was 18,75% (haze and ectasia). Conclusion: Non-simultaneous CXL and PRK procedures yielded good refractive results, but worse than those obtained with PRK alone. Although one patient in the PRK group developed corneal ectasia, the CXL + PRK group had a higher loss of vision lines, indicating less safety.
ISSN:0301-4738
1998-3689

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