Identification of pathogenic GCK variants in patients with common type 2 diabetes can lead to discontinuation of pharmacological treatment

Identification of pathogenic GCK variants in patients with common type 2 diabetes can lead to discontinuation of pharmacological treatment

Background: Functionally disruptive variants in the glucokinase gene (GCK) cause a form of mild non-progressive hyperglycemia, which does not require pharmacological treatment. A substantial proportion of patients with type 2 diabetes (T2D) carry GCK variants. We aimed to investigate whether carrier...

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Bibliographic Details
Main Authors: Anne Cathrine Baun Thuesen, Rasmus Tanderup Jensen, Henrik Maagensen, Maja Refshauge Kristiansen, Henrik Toft Sørensen, Allan Vaag, Henning Beck-Nielsen, Oluf B. Pedersen, Niels Grarup, Jens Steen Nielsen, Jørgen Rungby, Anette Prior Gjesing, Heidi Storgaard, Tina Vilsbøll, Torben Hansen
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
T2D (type 2 diabetes)
MODY (maturity-onset diabetes of the young)
Diagnosis
Treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426923000186

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