Maternal High-Fat Diet and Offspring Hypertension
The incidence of hypertension has increased to epidemic levels in the past decades. Increasing evidence reveals that maternal dietary habits play a crucial role in the development of hypertension in adult offspring. In humans, increased fat consumption has been considered responsible for obesity and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/15/8179 |
| _version_ | 1797413739240095744 |
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| author | You-Lin Tain Chien-Ning Hsu |
| author_facet | You-Lin Tain Chien-Ning Hsu |
| author_sort | You-Lin Tain |
| collection | DOAJ |
| description | The incidence of hypertension has increased to epidemic levels in the past decades. Increasing evidence reveals that maternal dietary habits play a crucial role in the development of hypertension in adult offspring. In humans, increased fat consumption has been considered responsible for obesity and associated diseases. Maternal diets rich in saturated fats have been widely employed in animal models to study various adverse offspring outcomes. In this review, we discussed current evidence linking maternal high-fat diet to offspring hypertension. We also provided an in-depth overview of the potential mechanisms underlying hypertension of developmental origins that are programmed by maternal high-fat intake from animal studies. Furthermore, this review also presented an overview of how reprogramming interventions can prevent maternal high-fat-diet-induced hypertension in adult offspring. Overall, recent advances in understanding mechanisms behind programming and reprogramming of maternal high-fat diet on hypertension of developmental origins might provide the answers to curtail this epidemic. Still, more research is needed to translate research findings into practice. |
| first_indexed | 2024-03-09T05:22:50Z |
| format | Article |
| id | doaj.art-1696de90056f4d6f9557a8422a6a8a4a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:22:50Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1696de90056f4d6f9557a8422a6a8a4a2023-12-03T12:38:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315817910.3390/ijms23158179Maternal High-Fat Diet and Offspring HypertensionYou-Lin Tain0Chien-Ning Hsu1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanDepartment of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanThe incidence of hypertension has increased to epidemic levels in the past decades. Increasing evidence reveals that maternal dietary habits play a crucial role in the development of hypertension in adult offspring. In humans, increased fat consumption has been considered responsible for obesity and associated diseases. Maternal diets rich in saturated fats have been widely employed in animal models to study various adverse offspring outcomes. In this review, we discussed current evidence linking maternal high-fat diet to offspring hypertension. We also provided an in-depth overview of the potential mechanisms underlying hypertension of developmental origins that are programmed by maternal high-fat intake from animal studies. Furthermore, this review also presented an overview of how reprogramming interventions can prevent maternal high-fat-diet-induced hypertension in adult offspring. Overall, recent advances in understanding mechanisms behind programming and reprogramming of maternal high-fat diet on hypertension of developmental origins might provide the answers to curtail this epidemic. Still, more research is needed to translate research findings into practice.https://www.mdpi.com/1422-0067/23/15/8179hypertensionhigh-fat dietdevelopmental origins of health and disease (DOHaD)oxidative stressnitric oxiderenin-angiotensin system |
| spellingShingle | You-Lin Tain Chien-Ning Hsu Maternal High-Fat Diet and Offspring Hypertension International Journal of Molecular Sciences hypertension high-fat diet developmental origins of health and disease (DOHaD) oxidative stress nitric oxide renin-angiotensin system |
| title | Maternal High-Fat Diet and Offspring Hypertension |
| title_full | Maternal High-Fat Diet and Offspring Hypertension |
| title_fullStr | Maternal High-Fat Diet and Offspring Hypertension |
| title_full_unstemmed | Maternal High-Fat Diet and Offspring Hypertension |
| title_short | Maternal High-Fat Diet and Offspring Hypertension |
| title_sort | maternal high fat diet and offspring hypertension |
| topic | hypertension high-fat diet developmental origins of health and disease (DOHaD) oxidative stress nitric oxide renin-angiotensin system |
| url | https://www.mdpi.com/1422-0067/23/15/8179 |
| work_keys_str_mv | AT youlintain maternalhighfatdietandoffspringhypertension AT chienninghsu maternalhighfatdietandoffspringhypertension |