Chemopreventive effect of Quercus infectoria galls on DMBA induced mouse skin tumorigenesis
Chemoprevention is an important strategy to control the process of carcinogenesis and a number of plants with anti-cancer properties are being researched, some of which have shown promising results. Quercus infectoria galls is a well-known medicinal plant which has been used in medicine as larvicida...
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| Format: | Article |
| Language: | Arabic |
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University of Mosul, College of Veterinary Medicine
2021-01-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_165318_d3c76adaf5b8de05a5b0342676cf921c.pdf |
| _version_ | 1819057737403727872 |
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| author | Sherzad Mustafa Bushra M. Mohammed |
| author_facet | Sherzad Mustafa Bushra M. Mohammed |
| author_sort | Sherzad Mustafa |
| collection | DOAJ |
| description | Chemoprevention is an important strategy to control the process of carcinogenesis and a number of plants with anti-cancer properties are being researched, some of which have shown promising results. Quercus infectoria galls is a well-known medicinal plant which has been used in medicine as larvicidal, anti-inflammatory, antibacterial, anti-fungal, antioxidant, and antidiabetic properties. The present study was carried out to evaluate the anti-tumor activity of the aqueous extract on the two stage process of skin carcinogenesis, consisting of initiation with a single topical application of a carcinogen 7, 12 - dimethylbenz (a) anthracene (DMBA) followed by a promoter (croton oil) three times in a week were employed. A significant reduction in tumor incidence, tumor burden, tumor yield, and cumulative number of papilloma was observed, along with a significant increase in average latent period in mice treated orally with 2 gm/kg of Quercus infectoria galls extract as compared to the positive control group treated with DMBA plus croton oil administered. Furthermore, Histopathological alterations in the carcinogen-treated control animals were also observed in the form of epidermal hyperplasia, keratinized pearl formation, and acanthosis in skin and tumors, whereas these were found to be reduced significantly before and after galls extract oral administration. The results thus concluded that Quercus infectoria galls extract exhibits significant anti-tumor activity and may serve in future drug development programs for the cancer prevention of skin cancer. |
| first_indexed | 2024-12-21T13:44:04Z |
| format | Article |
| id | doaj.art-169724ddeeef4db9a228a668c4760373 |
| institution | Directory Open Access Journal |
| issn | 1607-3894 2071-1255 |
| language | Arabic |
| last_indexed | 2024-12-21T13:44:04Z |
| publishDate | 2021-01-01 |
| publisher | University of Mosul, College of Veterinary Medicine |
| record_format | Article |
| series | Iraqi Journal of Veterinary Sciences |
| spelling | doaj.art-169724ddeeef4db9a228a668c47603732022-12-21T19:01:55ZaraUniversity of Mosul, College of Veterinary MedicineIraqi Journal of Veterinary Sciences1607-38942071-12552021-01-01351576210.33899/ijvs.2019.126267.1281165318Chemopreventive effect of Quercus infectoria galls on DMBA induced mouse skin tumorigenesisSherzad Mustafa0Bushra M. Mohammed1Pathology and Microbiology, Veterinary Medicine College, Duhok UniversityDepartment of Biology, College of Science ,University of Duhok, , Duhok ,IraqChemoprevention is an important strategy to control the process of carcinogenesis and a number of plants with anti-cancer properties are being researched, some of which have shown promising results. Quercus infectoria galls is a well-known medicinal plant which has been used in medicine as larvicidal, anti-inflammatory, antibacterial, anti-fungal, antioxidant, and antidiabetic properties. The present study was carried out to evaluate the anti-tumor activity of the aqueous extract on the two stage process of skin carcinogenesis, consisting of initiation with a single topical application of a carcinogen 7, 12 - dimethylbenz (a) anthracene (DMBA) followed by a promoter (croton oil) three times in a week were employed. A significant reduction in tumor incidence, tumor burden, tumor yield, and cumulative number of papilloma was observed, along with a significant increase in average latent period in mice treated orally with 2 gm/kg of Quercus infectoria galls extract as compared to the positive control group treated with DMBA plus croton oil administered. Furthermore, Histopathological alterations in the carcinogen-treated control animals were also observed in the form of epidermal hyperplasia, keratinized pearl formation, and acanthosis in skin and tumors, whereas these were found to be reduced significantly before and after galls extract oral administration. The results thus concluded that Quercus infectoria galls extract exhibits significant anti-tumor activity and may serve in future drug development programs for the cancer prevention of skin cancer.https://vetmedmosul.com/article_165318_d3c76adaf5b8de05a5b0342676cf921c.pdfskin carcinogenesischemopreventionantioxidantshistopathological alterationsquercus infectoria galls |
| spellingShingle | Sherzad Mustafa Bushra M. Mohammed Chemopreventive effect of Quercus infectoria galls on DMBA induced mouse skin tumorigenesis Iraqi Journal of Veterinary Sciences skin carcinogenesis chemoprevention antioxidants histopathological alterations quercus infectoria galls |
| title | Chemopreventive effect of Quercus infectoria galls on DMBA induced mouse skin tumorigenesis |
| title_full | Chemopreventive effect of Quercus infectoria galls on DMBA induced mouse skin tumorigenesis |
| title_fullStr | Chemopreventive effect of Quercus infectoria galls on DMBA induced mouse skin tumorigenesis |
| title_full_unstemmed | Chemopreventive effect of Quercus infectoria galls on DMBA induced mouse skin tumorigenesis |
| title_short | Chemopreventive effect of Quercus infectoria galls on DMBA induced mouse skin tumorigenesis |
| title_sort | chemopreventive effect of quercus infectoria galls on dmba induced mouse skin tumorigenesis |
| topic | skin carcinogenesis chemoprevention antioxidants histopathological alterations quercus infectoria galls |
| url | https://vetmedmosul.com/article_165318_d3c76adaf5b8de05a5b0342676cf921c.pdf |
| work_keys_str_mv | AT sherzadmustafa chemopreventiveeffectofquercusinfectoriagallsondmbainducedmouseskintumorigenesis AT bushrammohammed chemopreventiveeffectofquercusinfectoriagallsondmbainducedmouseskintumorigenesis |