Effect of Span 20 Feeding Zone in the Twin Screw Extruder on the Properties of Amorphous Solid Dispersion of Ritonavir

Effect of Span 20 Feeding Zone in the Twin Screw Extruder on the Properties of Amorphous Solid Dispersion of Ritonavir

A ternary amorphous solid dispersion (ASD) system consisting of drug/polymer/surfactant is receiving increased attention to improve the oral bioavailability of poorly water-soluble drugs. The effect of polymers has been extensively studied, while the impact of surfactants has not yet to be studied t...

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Bibliographic Details
Main Authors: Hengqian Wu, Zhengping Wang, Yanna Zhao, Yan Gao, Heng Zhang, Lili Wang, Zhe Wang, Jun Han
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersion
hot-melt extrusion
ritonavir
Span 20
precipitation
Online Access:https://www.mdpi.com/1999-4923/15/2/441

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