Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice
Left ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology an...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/757 |
| _version_ | 1797613317954469888 |
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| author | Fouad Khalil Rabea Asleh Radha Kanneganti Perue Jean-Marc Weinstein Adam Solomon Batya Betesh-Abay Alexandros Briasoulis Hilmi Alnsasra |
| author_facet | Fouad Khalil Rabea Asleh Radha Kanneganti Perue Jean-Marc Weinstein Adam Solomon Batya Betesh-Abay Alexandros Briasoulis Hilmi Alnsasra |
| author_sort | Fouad Khalil |
| collection | DOAJ |
| description | Left ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology and complications have been linked to their use. While the newer CF-LVAD generations have led to a reduction in some vascular complications such as stroke, no major improvement was noticed in the rate of other vascular complications such as gastrointestinal bleeding. This review attempts to provide a comprehensive summary of the effects of CF-LVAD on vasculature, including pathophysiology, clinical implications, and future directions. |
| first_indexed | 2024-03-11T06:53:13Z |
| format | Article |
| id | doaj.art-169955e829aa48f7b3fc04b26408b536 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:13Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-169955e829aa48f7b3fc04b26408b5362023-11-17T09:45:10ZengMDPI AGBiomedicines2227-90592023-03-0111375710.3390/biomedicines11030757Vascular Function in Continuous Flow LVADs: Implications for Clinical PracticeFouad Khalil0Rabea Asleh1Radha Kanneganti Perue2Jean-Marc Weinstein3Adam Solomon4Batya Betesh-Abay5Alexandros Briasoulis6Hilmi Alnsasra7Department of Internal Medicine, University of South Dakota, Sioux Falls, SD 57105, USAHeart Institute, Hadassah University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem P.O. Box 12000, IsraelDepartment of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USAFaculty of Health Sciences, Ben Gurion University of the Negev, Beersheva P.O. Box 653, IsraelFaculty of Health Sciences, Ben Gurion University of the Negev, Beersheva P.O. Box 653, IsraelFaculty of Health Sciences, Ben Gurion University of the Negev, Beersheva P.O. Box 653, IsraelDepartment of Cardiovascular Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902, USALeft ventricular assist devices (LVADs) have been increasingly used in patients with advanced heart failure, either as a destination therapy or as a bridge to heart transplant. Continuous flow (CF) LVADs have revolutionized advanced heart failure treatment. However, significant vascular pathology and complications have been linked to their use. While the newer CF-LVAD generations have led to a reduction in some vascular complications such as stroke, no major improvement was noticed in the rate of other vascular complications such as gastrointestinal bleeding. This review attempts to provide a comprehensive summary of the effects of CF-LVAD on vasculature, including pathophysiology, clinical implications, and future directions.https://www.mdpi.com/2227-9059/11/3/757continuous flow left ventricular assist devicegastrointestinal bleedingstrokepulmonary hypertensionperipheral artery diseasecoronary artery disease |
| spellingShingle | Fouad Khalil Rabea Asleh Radha Kanneganti Perue Jean-Marc Weinstein Adam Solomon Batya Betesh-Abay Alexandros Briasoulis Hilmi Alnsasra Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice Biomedicines continuous flow left ventricular assist device gastrointestinal bleeding stroke pulmonary hypertension peripheral artery disease coronary artery disease |
| title | Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice |
| title_full | Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice |
| title_fullStr | Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice |
| title_full_unstemmed | Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice |
| title_short | Vascular Function in Continuous Flow LVADs: Implications for Clinical Practice |
| title_sort | vascular function in continuous flow lvads implications for clinical practice |
| topic | continuous flow left ventricular assist device gastrointestinal bleeding stroke pulmonary hypertension peripheral artery disease coronary artery disease |
| url | https://www.mdpi.com/2227-9059/11/3/757 |
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