The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis
Objective: The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia. Methods: Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model. Results: The pooled SMD between case and con...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-04-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2019.1581215 |
| Summary: | Objective: The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia. Methods: Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model. Results: The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006). Conclusion: The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease. |
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| ISSN: | 1064-1955 1525-6065 |