Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin
This review is devoted to pharmacological characteristics, action mechanisms, hypolipidemic activity, and pleiotropic effects of a new hypolipidemic medication – ezetimibe, inhibiting intestinal cholesterol absorption. The combination of ezetimibe with other hypolipidemic drugs (statins, fibrates, b...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2005-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/993 |
| _version_ | 1827064142454849536 |
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| author | D. M. Aronov |
| author_facet | D. M. Aronov |
| author_sort | D. M. Aronov |
| collection | DOAJ |
| description | This review is devoted to pharmacological characteristics, action mechanisms, hypolipidemic activity, and pleiotropic effects of a new hypolipidemic medication – ezetimibe, inhibiting intestinal cholesterol absorption. The combination of ezetimibe with other hypolipidemic drugs (statins, fibrates, bile acid sequestrants) is described in detail. Initial doses of various statins, together with one tablet (10 mg) of ezetimibe, reduce low-density cholesterol level as effectively as maximal statin doses. |
| first_indexed | 2024-04-10T03:41:18Z |
| format | Article |
| id | doaj.art-169ba388308d4762bc0734e86fe19a8a |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2025-03-19T22:42:27Z |
| publishDate | 2005-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-169ba388308d4762bc0734e86fe19a8a2024-10-17T12:21:23Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252005-08-014491100707Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatinD. M. Aronov0State Research Center for Preventive Medicine, Ministry of Health of the Russian Federation, MoscowThis review is devoted to pharmacological characteristics, action mechanisms, hypolipidemic activity, and pleiotropic effects of a new hypolipidemic medication – ezetimibe, inhibiting intestinal cholesterol absorption. The combination of ezetimibe with other hypolipidemic drugs (statins, fibrates, bile acid sequestrants) is described in detail. Initial doses of various statins, together with one tablet (10 mg) of ezetimibe, reduce low-density cholesterol level as effectively as maximal statin doses.https://cardiovascular.elpub.ru/jour/article/view/993cholesterol absorption inhibitioncombined hypolipidemic therapyezetimibestatins |
| spellingShingle | D. M. Aronov Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin Кардиоваскулярная терапия и профилактика cholesterol absorption inhibition combined hypolipidemic therapy ezetimibe statins |
| title | Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin |
| title_full | Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin |
| title_fullStr | Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin |
| title_full_unstemmed | Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin |
| title_short | Simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin |
| title_sort | simultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatin |
| topic | cholesterol absorption inhibition combined hypolipidemic therapy ezetimibe statins |
| url | https://cardiovascular.elpub.ru/jour/article/view/993 |
| work_keys_str_mv | AT dmaronov simultaneousinhibitionofcholesterolabsorptionandsynthesisincombinedtherapywithezetimibeandsimvastatin |